Background: Development of venous thromboembolism (VTE), as well as arterial thrombosis is associated with the presence of inherited and acquired risk factors. Despite the current advances in research, unfortunately, a lot of questions remain unanswered. For instance, despite the coincidence of several risk factors for VTE, in some patients the thrombotic episode will not be developed. On the other hand, in some individuals, despite the absence of risk factors, thromboembolic event is diagnosed repeatedly.
Aims: The assessment of the influence of inherited and acquired risk factors on the development of arterial and venous thrombosis.
Methods: The authors analyzed risk factors and circumstances of the development of thromboembolism in patients followed-up for the management of thrombosis in the National Center of Hemostasis and Thrombosis.
Results: In this complex study, the authors confirmed the influence of acquired risk factors, such as polytrauma, surgical intervention, renal failure, immobilisation, pregnancy, inflammation, travelling and malignancy on the higher risk of arterial and venous thrombosis. In selected groups of patients, they evaluated the influence of acquired risk factors including increase in factor VIII activity, protein S and antithrombin deficiency on the development of thromboembolic complications. The most common form of arterial thrombosis was ischemic stroke present in 7.4% of the patients, the commonest form of venous thromboembolism ws deep venous thrombosis of lower extremities developed in 42.6% of the cases. Pregnancy complications occurred in 7.4%.
Conclusions: The results of laboratory parameters may contribute to individualization of primary or secondary thromboprophylaxis and increase the quality of life of affected persons.
Acknowledgements: Authors thank the support of the projects of the Scientific Grant Agency (Vega) 1/0549/19 and Agency for the Support of Research and Development APVV-16-0020.
To cite this abstract in AMA style:Stanciakova L, Chromekova K, Vajdova K, Dobrotova M, Holly P, Brunclikova M, Bolek T, Samos M, Kubisz P, Stasko J. How to Use the Data about Risk Factors for Thrombosis in Practice [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/how-to-use-the-data-about-risk-factors-for-thrombosis-in-practice/. Accessed November 28, 2021.
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