Abstract Number: PB1205
Meeting: ISTH 2021 Congress
Background: Venous thromboembolism (VTE) spectrum recently has been considered as second life-threatening cause after infection among primary glomerulonephritis with nephrotic syndrome (NS) patients. Based on the previous studies, there is inconclusive results whether proteinuria and hypoalbuminemia, which are hallmarks of NS patients, are associated with VTE incidence.
Aims: This study aims to measure the association between proteinuria and hypoalbuminemia with the VTE incidence among NS patients.
Methods: We searched comprehensively in online databases of Pubmed, ScienceDirect, EMBASE, and The Cochrane Library, to include all relevant studies from 2000 until 2021. We followed the PRISMA guideline for conducting this study. We included all cohort studies that access the association between proteinuria and hypoalbuminemia with the VTE incidence among primary glomerulopathies NS patients. Bias risk were accessed by using The Newcastle-Ottawa Scale for cohort study. Analysis was performed to provide pooled risk ratio (RR) with 95% confidence interval (CI) using random-effect heterogeneity test.
Results: We included 10 cohort studies matched our inclusion criteria. Patients with proteinuria above 3.5 g/day is associated with increased VTE risk although statistically not significant. (pooled RR = 1.11, 95% CI 0.99-1.25, p=0.06, I2=76%). Otherwise, NS patients whose hypoalbuminemia below 3 g/dL are associated with significant incremental VTE incidence risk (pooled RR = 1.41, 95% CI 1.13-1.74, p=0.002, I2=78%).
Conclusions: Hypoalbuminemia, not proteinuria, is associated with increased VTE incidence among primary glomerulonephritis with nephrotic syndrome patients. However, further studies are needed to establish the association and causality.
To cite this abstract in AMA style:Putra BP, Putra FN. Hypoalbuminemia, Not Proteinuria, Is Associated with Increased Venous Thromboembolism Risk among Primary Glomerulonephritis Patients with Nephrotic Syndrome: A Meta-analysis of Cohort Studies [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/hypoalbuminemia-not-proteinuria-is-associated-with-increased-venous-thromboembolism-risk-among-primary-glomerulonephritis-patients-with-nephrotic-syndrome-a-meta-analysis-of-cohort-studies/. Accessed November 29, 2021.
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