Abstract Number: PB0555
Meeting: ISTH 2021 Congress
Background: Previously Lagos University Teaching Hospital Haemophilia Treatment Center (HTC) has over 60 people with hemophilia (PWH) but severity level and inhibitor status were mostly unknown. Majority of PWH cannot afford cost of test. Clinical management were based on clinical history and trial with factor VIII and IX concentrate. We applied for funding from Research Support Program of World Federation of Hemophilia World Bleeding Disorders Registry (WBDR), which enabled us to identify severity and inhibitor status.
Aims: To offer diagnostic and inhibitor testing to PWH and to complete clinical data.
Methods: Our research was cross-sectional study. In Q4 2018, we had 12 PWH registered in the WBDR. We conducted educational sessions and outreach to encourage all PWH to attend our HTC for accurate diagnosis of their hemophilia type, severity and inhibitor status. We used the fund to pay for storage of testing materials, diagnostic kits and laboratory charges.
Results: We were able to accurately determine hemophilia type, severity level, and inhibitor status for 60 additional PWH. In Q1 2021, we have clinical data of 79 male PWH; 67 PWH were diagnosed with Hem A, 9 with Hem B and 3 are awaiting results. For Hem A, 43, 14 and 2 were diagnosed as severe, moderate and mild, and 8 are waiting to run the severity test. For Hem B, 4 and 1 were identified as severe and moderate, and 4 are waiting to test severity. Eight of 77 (10%) (7 Hem A, 1 Hem B) PWH were diagnosed with an inhibitor (mixing study).
Conclusions: The fund allowed us to identify, diagnose and provide clinical data of PWH in Southwest Nigeria. We use the WBDR to store data, which is useful when the National Registry does not exist. With complete and easy to access data set through the WBDR, we have better interaction with the PWH.
To cite this abstract in AMA style:Adeyemo T, Bolarinwa A, Adiat L, Olatinwo A, Opadeyi O, Otokiti O, Youttananukorn T, Coffin D. Identify Clinical and Laboratory Phenotypes of People with Hemophilia in Southwest Nigeria [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/identify-clinical-and-laboratory-phenotypes-of-people-with-hemophilia-in-southwest-nigeria/. Accessed September 16, 2021.
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