Abstract Number: VPB0610
Meeting: ISTH 2022 Congress
Background: Cytokines are signaling molecules and involve lymphocytes and macrophages in the immune response. Lymphocyte-platelet adhesion is one of the mechanisms that ensure the cooperation of various subpopulations of cells and allow them to migrate through the vascular wall into the tissue.
Aims: To study the function of lymphocyte-platelet adhesion depending on SNP of IL-2 (T330G) gene in healthy subjects and patients with COVID-19.
Methods: The research involved 168 patients with COVID-19 and 100 healthy people of the same age and gender. The participants of the study were Caucasian race and lived in the Trans-Baikal Territory. The examine of LPA was carried out by the method of Yuri Vitkovsky et al. (1999). The SNP of IL-2 (T330G) gene was determined by PCR. Such methods as Equilibrium Hardy-Weinberg, χ2-test, odds ratio descriptive statistics and the mean values (M) and standard deviation (SD) were used. Statistical significance was measured at the value p < 0.05.
Results: We found all the studied IL-2 mutations in accordance with the Hardy-Weinberg law (p>0.05). The heterozygous T/G of IL-2 gene was registered significantly more frequently in the group of patients in comparison with the control group. Based on the obtained data on frequency distribution, the chance of developing SARS-COV-2 increased in carriers of the allele T and the T/T genotype of IL-2 gene (p < 0.001). It was found that patients with SARS-COV-2 had a increase in the LPA index compared to the group of healthy individuals (15.2±1.1%). The maximum amount of LPA was detected among patients with T/T genotype – 39.7±2.1%, the minimum amount – in the owners of G/G (31.4±1.9%) (p< \0.001).
Conclusion(s): 1) SARS-COV-2 is accompanied by an increase in LPA function indicators, which depend on SNP of IL-2 (T330G) gene. 2) Carriers of allele T and T/T genotype of IL-2 gene (T330G) predispose to the development of COVID-19.
To cite this abstract in AMA style:Emelyanov A, Emelyanova A, Zaytseva E, Vitkovsky Y. IL-2 (T330G) gene promoter polymorphism and its effect on lymphocyte-platelet adhesion in patients with coronavirus infection SARS-COV-2 (COVID-19) [abstract]. https://abstracts.isth.org/abstract/il-2-t330g-gene-promoter-polymorphism-and-its-effect-on-lymphocyte-platelet-adhesion-in-patients-with-coronavirus-infection-sars-cov-2-covid-19/. Accessed September 22, 2023.
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