Background: Acute coronary syndrome (ACS) comprises of ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI) and unstable angina (UA). Platelet plays important roles in ACS pathogenesis. Immature platelet fraction (IPF) and platelet indices can reflect platelet activations. Platelet indices consist of platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).

Aims: This study aimed to analyze the differences in number of IPF and platelet indices among ACS patients.

Methods: This study was an observational analytical cross sectional study conducted at the Dr. Soetomo Hospital, Surabaya, Indonesia, during May to September 2019. The EDTA-samples were performed for IPF and platelet indices using Sysmex XN-1000. This study was approved by ethical clearance committee of Dr. Soetomo Hospital. Informed consents were taken from all study subjects. The differences of IPF and platelet indices among STEMI, NSTEMI, and UA patients were analyzed using Kruskall-Wallis and Mann-Whitney test.

Results: The subjects were consisted of 30 STEMI, 25 NSTEMI and 24 UA patients. The IPF values showed significantly difference between groups (p< 0.001), with the highest median value is STEMI, and be followed by NSTEMI and UA groups.The value of MPV, PDW, and P-LCR showed significantly higher in STEMI towards UA (p< 0.001 for each parameter), and NSTEMI towards UA (p=0.002; p< 0.001; p< 0.001 respectively for each parameter).

Conclusions: The IPF values can be considered as an alternative indicator to differentiate the STEMI, NSTEMI and UA. The MPV, PDW, and P-LCR can be considerd as an alternative indicator to differentiate STEMI and UA, and also NSTEMI and UA.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/immature-platelet-fraction-and-platelet-indices-in-acute-coronary-syndrome/