Abstract Number: PB0825
Meeting: ISTH 2021 Congress
Background: Immature platelet fraction (IPF) has been shown to be a useful marker in thrombocytopenia cause identification. Moreover, there are reports showing that IPF can predict platelet recovery and response to treatment in various conditions, including immune thrombocytopenia (ITP.) However, in patients with thrombocytopenia related to systemic lupus erythematosus (SLE), IPF range and usefulness in response prediction is not well-studied.
Aims: Identify the range of IPF in SLE-related thrombocytopenia patients and its value as a predictor for early platelet response to treatment.
Methods: Newly diagnosed SLE patients with platelet counts < 50 x 109/L were recruited to our study. All patients received methylprednisolone, hydroxychloroquine and an immunomodulating agent. Blood samples were collected on the first day of treatment and 48 hours later for complete blood count and IPF testing. Patients who received platelet transfusion during the 48-hour follow-up were excluded. Also, SLE Disease Activity Index (SLEDAI) was evaluated in each patient at the start of treatment.
Results: 16 patients were recruited in this preliminary study. Mean baseline platelet count and IPF values were 32.63 ± 22.97 x 109/L and 19.16 ± 17.96 %, respectively. The 95% confidence interval (95% CI) of IPF was 9.59 – 28.73 %. Baseline IPF did not significantly correlate with baseline platelet count and SLEDAI (p > 0.05.) However, baseline IPF had a significant correlation with platelet count change after 48 hours (p < 0.01, correlation coefficient 0.68) (Figure 1)
Conclusions: Our early data shows that unlike ITP, in which hyperdestruction the main etiology of platelet consumption, SLE-related thrombocytopenia may involve multiple mechanisms, as the 95% CI of IPF was wide and IPF did not correlate with baseline platelet count and SLEDAI. Finally, IPF seems to be a promising predictor for early platelet response for treatment in this patient population. More data is required to confirm these early findings.
To cite this abstract in AMA style:Nguyen T, Truong-Pham D, Huynh T, Nguyen T, Tran T, Phan-Nguyen L, Nguyen-Tran G, Tran T. Immature Platelet Fraction in Systemic Lupus Erythematosus-Related Thrombocytopenia: Potential Predictor of Platelet Response to Treatment? [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/immature-platelet-fraction-in-systemic-lupus-erythematosus-related-thrombocytopenia-potential-predictor-of-platelet-response-to-treatment/. Accessed September 16, 2021.
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