Abstract Number: PB0987
Meeting: ISTH 2022 Congress
Background: One of the most recent advances to improve blood safety and lower the risk of transfusion-transmitted diseases is the pathogen reduction treatment (PRT) of platelet concentrates (PCs). The characteristics of PR-treated PCs slightly differ from those of untreated PCs, and may affect transfusion outcome.
Aims: The aim of this research project is to see how effective amotosalen/UVA (INTERCEPT TM Blood System) PCs are when transfused to a group of cardiac surgery patients.
Methods: This study examined the influence of the PRT using amotosalen‐HCl and UVA light in a population of cardiac surgery patients.We analyzed the bleeding and platelet drop postoperatively in cardiac surgery with extracorporeal circulation. We selected 73 PCs after taking into account the medical exclusion criteria: 46 PCs without pathogen reduction treatment/Intercept® versus 27 PCs with pathogen reduction treatment/Intercept®.
Results: The decrease of patient platelet count between preoperative and H0 (start of surgery), preoperative and H6 (6 hours after) did not differ significantly with or without PRT. The volume of postoperative bleeding from cardiac surgery under extracorporeal circulation did not differ significantly regardless on whether the patient was transfused with PRT-PC or untreated PC. No difference was found in the number of postoperative pneumopathies between the groups. Moreover, independently of the use of PRT for platelets we observed an inverse correlation between preoperative fibrinogen and bleeding at 24 hours (post-surgery). A 1 mg/L increase in fibrinogen (preoperative) is associated with a 159 mL decrease in bleeding 24 hours after the start of the surgery.
Conclusion(s): In postoperative cardiac surgery, the use of platelets treated with amotosalen/UVA (INTERCEPT TM Blood System) for pathogen reduction does not appear to affect transfusion effectiveness and postoperative bleeding.
To cite this abstract in AMA style:Belkacem B, Hamzeh-Cognasse H, Duchez A, Eyraud M, Arthaud C, Prier A, Audoux E, Ebermeyer T, Chavarin P, Kazra A, Morel J, Palao J, Cognasse F. Impact of amotosalen/UVA process for pathogen reduction in platelet concentrates on transfusion efficiency in cardiac surgery [abstract]. https://abstracts.isth.org/abstract/impact-of-amotosalen-uva-process-for-pathogen-reduction-in-platelet-concentrates-on-transfusion-efficiency-in-cardiac-surgery/. Accessed October 1, 2023.
« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/impact-of-amotosalen-uva-process-for-pathogen-reduction-in-platelet-concentrates-on-transfusion-efficiency-in-cardiac-surgery/