Abstract Number: PB2327
Meeting: ISTH 2020 Congress
Background: Studies investigating risk of venous thromboembolism (VTE) in men and women have had diverging results. In younger age groups, incidence is higher in women, while in older age groups, incidence is higher in men. Since men have higher mortality rates than women in all age groups, VTE incidence may be overestimated across all age groups of men. No study has investigated the gender-specific cumulative incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE) in a nationwide cohort, while taking into account the competing risk of death.
Aims: To assess the impact of the competing risk of death on cumulative incidence of DVT and PE in men and women within different age groups in a nationwide cohort.
Methods: The population of Denmark served as the source cohort. All persons with a first-time VTE in the period 1995-2016 were identified from the Danish National Registry of Patients. Age was used as the time scale, and the cumulative incidence function of DVT and PE was estimated in men and women after taking into account the competing risk of death.
Results: During follow-up, 124,890 incident VTEs (74,389 DVTs and 50,501 PEs) occurred. The cumulative incidence of DVT was higher in women than in men among persons aged < 60 years, but higher in men than in women among those aged >60 years (Figure 1A). The cumulative incidence of PE was higher in women than in men among persons aged < 60 years, while no difference was observed among those aged >60 years (Figure 1B).
Conclusions: When the competing risk of death was taken into account, the cumulative incidence of both DVT and PE was higher in women than in men in the younger age groups. In the elderly, the cumulative incidence of DVT was higher in men than in women. No sex difference was observed for PE.
To cite this abstract in AMA style:Arnesen CAL, Veres K, Skajaa N, Horváth-Puhó E, Sørensen HT, Hansen J-, Brækkan SK. Impact of Competing Risk of Death on the Cumulative Incidence of Venous Thromboembolism in a Nationwide Danish Cohort of Men and Women [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/impact-of-competing-risk-of-death-on-the-cumulative-incidence-of-venous-thromboembolism-in-a-nationwide-danish-cohort-of-men-and-women/. Accessed February 27, 2024.
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