Abstract Number: PB1287
Meeting: ISTH 2020 Congress
Background: A clear understanding of the association of inherited thrombophilias (IT) with perinatal arterial stroke (PAS) and its course has yet to be established. Recent case-control studies only reported small numbers of patients and grouped together different stroke entities.
Aims: Estimation of the impact of IT
i) on a first PAS and
ii) on the further course using a combined end point describing neurological outcome and thromboembolic recurrence.
Methods: Systematic search in electronic databases (PubMed, EMBASE, OVID, Web of Science, Cochrane Library) for studies published from 1986 to August 2019. Abstraction of data on year of publication, study design, country of origin, number of patients/ control subjects, ethnicity, stroke type. Calculation of summary odds ratio (OR) and 95% confidence interval (CI) with the fixed-effects- or random-effects-model.
Results:
i) Inclusion of 23 of 113 references. Analysis of 1027 patients and 2594 control subjects. We found no significant heterogeneity or publication bias. OR/ CI (fixed-effects-model): Factor V G1691A mutation 2,72/ 2,0 – 3,7; factor II G20210A variant 1,4/ 0,90 – 2,2; MTHFR T677T genotype 1,6/ 1,26 – 2,04.
ii) Evaluation of 4 of 23 studies on the combined study endpoint poor neurological outcome and recurrence rates with IT present: OR/ CI (relevant publication bias, random-effects-model): 5,8/ 1,35 – 24,81.
Conclusions:
i) Factor V G1691A mutation and MTHFR T677T genotype represent risk factors for PAS. In our analysis factor II G20210A variant does not yield a higher risk for a first PAS.
ii) Using the combined end point approach we found a statistically significant association of poor neurological outcome and recurrence rates with the presence of at least one inherited thrombophilia.
To cite this abstract in AMA style:
Bajorat T, Kiesau B, Shneyder M, Kuta PM, Kowalski D, Rocke A, Keneth G, Junker R, Nowak-Göttl U. Impact of Inherited Thrombophilia on Risk of a First Perinatal Arterial Stroke and Futher Course or Recurrence Rates: A Systematic Review and Meta-Analysis of Observational Studies [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/impact-of-inherited-thrombophilia-on-risk-of-a-first-perinatal-arterial-stroke-and-futher-course-or-recurrence-rates-a-systematic-review-and-meta-analysis-of-observational-studies/. Accessed September 27, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/impact-of-inherited-thrombophilia-on-risk-of-a-first-perinatal-arterial-stroke-and-futher-course-or-recurrence-rates-a-systematic-review-and-meta-analysis-of-observational-studies/