Abstract Number: PB0561
Meeting: ISTH 2021 Congress
Background: Hemophilic arthropathy and other hemophilia-associated co-morbidities may increase the likelihood of unemployment due to disability in people with hemophilia (PWH).
Aims: To assess the association between employment status and hemophilia treatment after adjusting for clinically relevant variables, potentially affecting employment status in PWH using baseline data from the ADVANCE study which aimed to assess the incidence of cardiovascular disease in older PWH.
Methods: Twenty hemophilia centers from 15 European countries recruited 791 participants aged 40 years and over with hemophilia A or B by August 2018. Analyses included descriptive statistics and logistic regression models.
Results: Employment status was available for 756 of 791 participants (85% hemophilia A) aged 40-88 years (mean 54 years). Employment status was self-assigned by each participant into one of six categories (n, %, mean age): full-time work (386, 51%, 50y), part-time work (71, 9%, 54y), early retirement (46, 6%, 56y), retired (150, 20%, 67y), unemployed disabled (64, 8%, 52y), and unemployed not disabled (39, 5%, 51y). In the regression analysis, we compared PWH in full-time employment with those unemployed due to disability, yielding a sample of 407 persons. In multivariable logistic regressions, age (OR=1.1, P <0.01), severe hemophilia (OR=11.7, P <0.001), current smoker (OR=2.4, P 0.01), and chronic liver disease (OR=1.9, P=0.05) were associated with higher odds of being unemployed due to disability, while prophylactic treatment (OR=0.4, P=0.01) was negatively associated with unemployment due to disability. There was no association with type of hemophilia, BMI, HIV+, or inhibitor (previous or current). The presence of a target joint was associated with unemployment due to disability (OR 2.2, p=0.01) in univariate analysis, but not in multivariable logistic regressions.
Conclusions: Adjusting for the severity of hemophilia, PWH on prophylactic treatment are less likely to be unemployed due to disability than those with on demand treatment.
To cite this abstract in AMA style:Holme PA, Qvigstad C, Tait RC. Impact of Prophylactic Treatment on Employment and Disability in Persons with Hemophilia [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/impact-of-prophylactic-treatment-on-employment-and-disability-in-persons-with-hemophilia/. Accessed September 16, 2021.
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