Abstract Number: PB2322
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » VTE Epidemiology
Background: Socioeconomic status (SES) affects the risk of incident venous thromboembolism (VTE), and VTE has long-term complications that influence functional activity and life quality. No previous study has investigated the effect of SES on the risk of work-related disability pension after VTE.
Aims: To investigate the combined effects of SES and incident VTE on work-related disability pension in the general population.
Methods: Using medical and administrative databases, a Danish nationwide cohort of 41,928 patients < 65 years with an incident VTE during 1995-2016 was established. An age,- sex,-and calendar-year-matched comparison cohort was identified from the general population < 65 years (n=209,640). Incident VTE and SES (categorized low, medium, high based on similar categories for education, employment, and income) were exposures and work-related disability pension outcome. Cox-regression models were used to compute hazard ratios (HRs) with 95% confidence intervals (CIs) in analyses stratified by sex, age-groups (25-39, 40-54, 55-64 years) and adjusted for comorbidities (cancer, CHD,diabetes, stroke, obesity and COPD). The reference group consisted of subjects with medium SES and no VTE.
Results: 41,928 subjects with incident were included whereof 3,893 were granted permanent work-related disability pension (incidence rate=13.0 per 1,000 person-years). Subjects 25-39 years with low SES without VTE had a 4.6-fold higher risk (HR 4.58, 95% CI: 4.08-5.14) of disability pension than the reference group. Low SES combined with incident VTE yielded a 13-fold increased risk of disability pension (HR 13.16, 95% CI: 11.65-14.86). Adjustment for comorbidities had modest effect on the risk estimate (HR 12.50, 95% CI: 11.07-14.13). This risk estimate decreased gradually with increasing age and displayed similar trends for both sexes.
Conclusions: Our results showed that SES affected the risk of work-related disability in patients with VTE, independent of comorbidities. This implies that awareness of SES is important when designing programs to reduce the social consequences and economic burden of VTE.
To cite this abstract in AMA style:
Jørgensen H, Horváth-Puhó E, Laugesen K, Braekkan S, Hansen J-, Sørensen HT. Impact of Socioeconomic Status on the Risk of Receiving a Permanent Work-Related Disability Pension After Incident Venous Thromboembolism [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/impact-of-socioeconomic-status-on-the-risk-of-receiving-a-permanent-work-related-disability-pension-after-incident-venous-thromboembolism/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
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