Abstract Number: PB0961
Meeting: ISTH 2020 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Hemophilia causes spontaneous bleeding in joints leading to a greater tendency to immobility and arthropathy. Decreased mobility implies lower physical activity and a sedentary lifestyle predisposing to an excess of weight (EOW). Weight excess is associated with loss of joint mobility, chronic pain and carries out a vicious cycle that generates susceptibility to arthropathy. Few data have been reported from middle-income countries.
Aims: To evaluate the implication of EOW in hemophilic arthropathy.
Methods: Subjects over five years old with a diagnosis of hemophilia A or B were included from a tertiary referral center in Bucaramanga, Colombia. Participants´ height and weight were measured to calculate body mass index (BMI). For children (< 16 years old), EOW was defined by WHO nutritional charts, whereas for adults, EOW was defined as a BMI ≥ 25 kg/m2. The association between independent variables and the presence of arthropathy was explored using the Chi-square test. A significance level of 5% was determined at two tails.
Results: Of 59 people with hemophilia (PWH), 51 (86.4%) had hemophilia A, and 8 (13.5%) had hemophilia B; 15 (25.3%) were classified as mild, 11 (18.6%) as moderate, and 33 (55.9%) as severe hemophilia; 41 (69.5%) had arthropathy, 13 (22%) had one joint compromise, and 28 (47.4%) had multiple joint compromises. The most frequently affected joint was knee (47.4%), followed by the ankle (38.9%) and elbow (33.9%). Mean BMI was 22.4 ± 4.84; 26 PWH (44.0%) had EOW. Those with EOW had a higher prevalence of one or multiple arthropathies compared with those with a normal weight (53.5% vs. 46.3% p = 0.025).
Conclusions: Prevalence of EOW is similar to the reported in high-income countries. Arthropathy was significantly higher in subjects with EOW; therefore, it is necessary to establish strategies for weight management, taking into account the specific characteristics of PWH.
To cite this abstract in AMA style:
Lopez-Lopez J, Sossa-Melo C, Peña-Castellanos A, Wandurraga EA, Ney-Salazar D, Otero-Wandurraga J. Implication of Weight Excess in Hemophilic Arthropathy. The Results of a Colombian Reference Center [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/implication-of-weight-excess-in-hemophilic-arthropathy-the-results-of-a-colombian-reference-center/. Accessed September 29, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/implication-of-weight-excess-in-hemophilic-arthropathy-the-results-of-a-colombian-reference-center/