Abstract Number: PO108
Meeting: ISTH 2021 Congress
Background: It is known that high-fat diet, induce hypercholesterolemia, deterioration of arterial wall, both morphologically and mechanically. Mechanical changes include thickening of arterial wall, alteration of arterial elasticity, contraction of smooth muscle, increase in sensitivity to pharmacological stimulation and increase in arterial viscoelasticity, i.e., arteriosclerosis. The management of stable fibroatheromatic plaque reduces the risk of ischemic diseases and its related deaths. Customary management options are invasive and include arterial atherectomy and stenting.
Aims: In this study, we developed an experimental electrohydraulic shock wave generator system (0–20 kv), and investigated its effectiveness on stable fibroatheromatic plaque regression in the hamster abdominal aorta, wherein diagnostic B-mode ultrasound is combined with shock wave therapy system, with a goal of increased safety.
Methods: Thick- cap fibroatheromatic plaque with severe stenosis (>80%) was induced at the right common carotid artery of Golden Syrian Hamsters. The animals treated by repeated electrohydraulic focused shock waves (V= 15 Kv, F= 0.5 Hz, Impulses= 100) accompanied by PESDA microbubbles (100 μl/kg, 2–5×105 bubbles/ml) and high-dose atorvastatin (5 mg/kg/day) administration. Arterial biomechanical parameters were evaluated in the different groups using B- mode ultrasound images.
Results: Results showed a significant reduction in the mean value for shear elastic modulus, resistive index and a significant increase in the mean value for radial strain, compliance and distensibility index in the treatment group compared with the other groups (P<0.05).
Conclusions: Enhanced inertial cavitation- mediated sonoporation effect of shock waves, induced by collapsed microbubbles accompanied by enhanced lipophilic and pleiotropic effects of atorvastatin- induced by high-dose administration, accompanied by anti- inflammatory effect of shock waves, can cause to reduce the lipid- laden cells in the plaque lipid core and significantly dilate the luminal cross-sectional area of stenosis and regress the thick- cap fibroatheromatic plaque. These features can cause to improve the arterial biomechanical parameters.
To cite this abstract in AMA style:Mehrad H, Ahmadi Noubari H. Improving of the of Biomechanical Parameters in an Experimental Animal Abdominal Aorta Model of Thick- cap Fibroatheromatic Plaque Using Ultrasound-guided High-dose Atorvastatin-loaded PESDA Microbubbles and Low Level Focused Shock Waves [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/improving-of-the-of-biomechanical-parameters-in-an-experimental-animal-abdominal-aorta-model-of-thick-cap-fibroatheromatic-plaque-using-ultrasound-guided-high-dose-atorvastatin-loaded-pesda-microbubb/. Accessed September 16, 2021.
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