Abstract Number: PB0763
Meeting: ISTH 2021 Congress
Background: Thrombocytopenia is a serious clinical consequence of certain blood and immunological disorders, tumors, drugs, and infections. Enormous literature is available addressing the incidence of thrombocytopenia following sepsis and viral infections. However, there is scant data revealing the association of blood stream infections with thrombocytopenia.
Aims: This study was designed to observe the impact of blood cultures on platelet count and also to find out the association between type of microbial organism and severity of thrombocytopenia.
Methods: An observational study was conducted at NIBD PECHS campus from July to December 2019 after institutional review board approval. The incidence of platelet count (x109/L) of <10, <50 and <100 were observed in patients having positive blood cultures. Chi square or Fisher’s exact test was used to observe the association and P value < 0.05 was considered significant.
Results: A total of 94 blood cultures were analyzed and correlated with the presence of thrombocytopenia. Forty four (47%) cultures were positive. The frequently encountered gram negative organism was Pseudomonas aeruginosa 16(43%) and gram positive was Staphylococcus aureus 3(43%). The incidence of thrombocytopenia in patients with positive and negative blood cultures were 39% and 20% respectively at platelet count of < 10 (P= 0.046). For platelet count (x109/L) < 50 and < 100, it was not found significant. However, The incidence of thrombocytopenia with respect to specific gram negative or positive organism was not found significant.
Conclusions: In our study, positive blood cultures were more inclined to have platelet count of <10×109/L but there was no significant impact of type of organism on platelet count. Thrombocytopenia is one of the grave and inevitable consequence of infections which may lead to mortality and morbidity. Future prospective studies are needed to fill the void in this aspect.
To cite this abstract in AMA style:Anwar N, Fatima N, - Mujtaba H-, Shamsi T. Incidence and Correlation of Thrombocytopenia to Blood Stream Infections; Does this Correlation Really Matter? [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/incidence-and-correlation-of-thrombocytopenia-to-blood-stream-infections-does-this-correlation-really-matter/. Accessed September 16, 2021.
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