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Incidence and Treatment Pattern of Venous Thromboembolism from 2014 to 2018: The 3rd Korean Nationwide Study

1Soonchunhyang University Gumi Hospital, Gumisi, Korea, Republic of, 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, 3Respiratory Division, Department of Internal Medicine Soonchunhyang University, School of Medicine, Seoul Hospital, Seoul, Korea, Republic of, 4Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea, Republic of, 5Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea, Republic of

Abstract Number: PB1207

Meeting: ISTH 2021 Congress

Theme: Venous Thromboembolism » VTE Epidemiology

Background: The incidence of venous thromboembolism (VTE) gradually increased in Korean population even though it is still low compared to western population.

Aims: The aim of the 3rd nationwide study is to evaluate the annual age- and sex-adjusted incidence rates (ASR) of VTE and to describe the trend of anticoagulation over years since direct oral anticoagulants (DOAC) from 2014 to 2018.

Methods: Using the Korean Health Insurance Review and Assessment Service (HIRA) database, VTE patients from 2014 to 2018 were retrospectively identified by both diagnostic codes and medication codes of anticoagulants used within 6 months of initial index event. DOAC-based regimen was defined as DOAC only or DOACs combined with UFH and/or LMWH except warfarin; LMWH and/or UFH regimen; warfarin-based regimen as warfarin only, or LMWH/warfarin; mixed anticoagulation regimen as anticoagulants including both warfarin and DOACs.

Results: We identified 95,205 individuals with VTE (54,085 female, 56.8%). The ASR of VTE, deep vein thrombosis (DVT) only, and pulmonary embolism with or without DVT (PE) per 100,000 individuals continued to increase from 32.83, 13.82 and 19.01 cases in 2014 to 53.66, 22.79 and 30.87 in 2018, respectively. The incidence rate for VTE was significantly higher in 2018 than in 2014 (relative risk [RR] of 1.63; 95% CI, 1.6 to 1.67; p-value<0.0001); among patients aged 80 or older than 30-39 age group (RR 25.40 95% CI, 24.63 to 26.18; p-value<0.0001); in female than male (RR 1.29; 95% CI, 1.28 to 1.31; p-value<0.0001). Among anticoagulants, the portion of DOACs-based prescription increased from 40.5% to 72.8%; UFH and/or LMWH decreased from 24.3 to 18.4%; warfarin-based prescription, from 27% to 5.6%/ mixed anticoagulation, from 8.2% to 3.2% in 2014 and 2018, respectively.
Sex- and age-adjusted annual incidence of VTE, DVT only and PE per 100,000 of VTE in 2014 and 2018
Trend of anticoagulants for VTE from 2014 to 2018

Conclusions: The ASR of VTE in Korea still continuously increased from 2014 to 2018. DOACs became main option for anticoagulation in two-third of VTE patients.

To cite this abstract in AMA style:

Hwang H-, Lee JH, -A Kim S, Kim Y-, Yhim H-, Hong J, S-B. Incidence and Treatment Pattern of Venous Thromboembolism from 2014 to 2018: The 3rd Korean Nationwide Study [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/incidence-and-treatment-pattern-of-venous-thromboembolism-from-2014-to-2018-the-3rd-korean-nationwide-study/. Accessed October 1, 2023.

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