Abstract Number: PB1206
Meeting: ISTH 2021 Congress
Background: Primary Hyperparathyroidism (HPTP) has been associated with cardiovascular events and inflammatory and prothrombotic markers. There are no studies that explore the occurrence of Venous ThromboEmbolism (VTE).
Aims: To estimate the incidence of VTE in patients with HPTP.
Methods: Retrospective cohort which included adult patients affiliated to an institutional prepaid-insurance (Hospital Italiano de Buenos Aires) between 1999-2019. HPTP diagnosis was defined as hypercalcemia (calcium value >10.5mg/dL or ionic calcium value >1,35mmol/L) and PTH measurement >77pg/dL, each case was individually confirmed by an expert review. Patients were followed up until the occurrence of VTE (deep vein thrombosis -DVT- and/or pulmonary thromboembolism -PE-), surgery, death or administrative censored. VTE events were captured from secondary databases (Institutional Registry of Thromboembolic Disease). No sample size calculation was performed because we included all eligible patients. Cumulative Incidence was estimated using Kaplan-Meier analysis. We reported different times (6 months and from 1 to 5 years) with their respective 95%CI.
Results: From a total of 1,354 potentially eligible patients, 653 were confirmed with HPTP by a specialist. The overall median follow-up of the cohort was 7.23 years with time at risk of 1,812,313 persons/days. A total of 28 VTE events occurred, 22 DVT and 6 PE, with a median of 1211 days (3.3 years). The incidence of VTE was: 0.15% (95%CI 0.02-1.08) at 6 months and 1-year, 1.07% (95%CI 0.51-2.24) at 2-year, 2.03% (95%CI 1.82-3.47) at 3-year, 2.87% (95%CI 1.82-4.53) at 4-year, and 3.24% (95%CI 2.10-4.98) at 5-year period. The median of PTH levels in patients who had VTE was 138 (IQR 101.7) and 157.5 (IQR 102.4) in patients without VTE. The mean of calcium levels in patients who had VTE was 11,72 (SD 0.32) and 11.93 (SD 0.75) in patients without VTE.
HPTP patients had an increased occurrence of VTE compared to the general population.
To cite this abstract in AMA style:Orlova M, Zin YJ, Posadas Martínez ML, Grande Ratti MF, Giunta DH, Burgos M, Vázquez FJ. Incidence of Venous Thromboembolic Disease during Primary Hyperparathyroidism: A 20-year Single Center Study [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/incidence-of-venous-thromboembolic-disease-during-primary-hyperparathyroidism-a-20-year-single-center-study/. Accessed September 23, 2021.
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