Background: Venous Thromboembolism a well-known complication in patents diagnosed with cancer. Lung cancer considered among the group of malignancies with the highest incidence rates of VTE.

Aims: To determine the incidence rates and assess the predictors associated with VTE and mortality in patients diagnosed with lung cancer.

Methods: In this two-centres study we retrospectively followed up 497 patients aged ≥18 years with a lung cancer. In this Saudi cohort study, the incidence of VTE and mortality were assessed. The association between characteristics of patients, VTE and mortality were explored by estimating hazard ratio (HR) and 95% confidence interval (CI) using univariate and multivariate cox regression.

Results: Of the 497 patients with lung cancer, 98 patients developed VTE and 280 patients died with an incidence rate of 9.8 per 100 person-year (PY,95%CI, 8.0-11.8) and 26.5 per 100 PY (95% CI, 23.9-29.3), respectively. Presence of NSCLC, low albumin level, and high grade of Eastern Cooperative Oncology Group (ECOG) performance status were found independent predictors associated with the development of VTE; Table 1. VTE carries a high mortality rate (HR, 3.10; 95%CI, 2.53-3.91; p

Conclusion(s): The incidence rate for VTE in lung cancer patients was 9.8 per 100 YP and the mortality was 26.5 per 100 PY. Presence of NSCLC, low albumin level, and high grade of ECOG performance status were significant predictors for VTE. Patients who developed VTE had 3.10-fold higher mortality rate than patients with no VTE.

Table

Table 1. Univariant and multivariant Cox Regression for predictors associated with recurrent VTE

Table

Table 2. Univariant and multivariant Cox Regression for predictors associated with death

« Back to ISTH 2022 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/incidences-and-predictors-of-venous-thromboembolism-and-mortality-in-patients-diagnosed-with-lung-cancer-among-saudi-population-retrospective-two-centre-cohort-study/