Infectious Complications in Hemophilia Patients

H. Khachatryan^1,2,3, G. Tamamyan^1,2, I. Melnichenko^1,2, L. Sahakyan¹, L. Petrosyan¹, S. Danelyan¹, S. Hovhannisyan^1,2, A. Movsisyan^1,2, L. Hambardzumyan^1,2, N. Sargsyan^4,2,3

¹Hematology Center after Prof. R.H. Yeolyan, Yerevan, Armenia, ²Yerevan State Medical University, Yerevan 0025, Armenia, ³Hemophilia Treatment Center, Yerevan, Armenia, ⁴Hematology Center named Prof. R.H. Yeolyan, Yerevan, Armenia

Abstract Number: PB0648

Meeting: ISTH 2021 Congress

Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical

Background: Replacement therapy increases factor VIII plasma level, which temporarily corrects its deficiency in the blood plasma and prevents bleeding. Replacement therapy has, in the past and now, influenced the treatment of patients. Before the use of modern factors, treatment for patients was traditionally with fresh frozen plasma, which has never been virally inactivated. Most people with hemophilia who treated with fresh frozen plasma were infected with the HIV virus, Hepatitis C, Hepatitis B and other blood-borne viruses.

Aims: The aim of the study is to analyze the incidence of infectious complications depending on the treatment and the severity of the disease. Important to investigate the prevalence of hepatitis among patients treated with fresh frozen plasma and VIII, IX concentrates, their distribution by age groups, by immunogenic complications.

Methods: The study was based on the registration data of the Armenian Hemophilia Center. Conducted a retrospective analysis of 271 patients (4.85% younger than 18 years of age) indicated the outpatient cards with HCV infection, HbSAg- in, HBcore-on in education. The data obtained were processed by statistical methods SPSS, χ2 and Student.

Results: According to the data obtained, infectious complications were registered only in patients of the I group. Infectious complications were found in 71 (33%) of 212 examined adult patients. Hepatitis C prevailed – 62 cases (87%) among the observed infectious complications; hepatitis B was detected in 8 patients (11%); hepatitis B and C were combined in 1 case (2%).

Conclusions: The use of factors in all types of severity excludes infection complications. The immunologic complications, the development of inhibitors, joint complications, in mild forms of diseases include a low percentage. Experience has shown that mild to moderate diseases of the disease go unnoticed. They have more frequent infectious complications, joint diseases, and therefore more frequent bleeding. Such a group goes unnoticed.

To cite this abstract in AMA style:

Khachatryan H, Tamamyan G, Melnichenko I, Sahakyan L, Petrosyan L, Danelyan S, Hovhannisyan S, Movsisyan A, Hambardzumyan L, Sargsyan N. Infectious Complications in Hemophilia Patients [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/infectious-complications-in-hemophilia-patients/. Accessed September 29, 2023.

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