Abstract Number: PB1879
Meeting: ISTH 2020 Congress
Background: iTTP is a potentially life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalized microvascular thrombosis in various organs. We (Falter et al.; Transfusion 2017;57:1152) and others reported that survivors of iTTP have a high prevalence of self-reported significant depression and impaired cognitive function.
Aims: The aim of the present study was to determine whether life circumstances and personality have an influence on the development and severity of depression and anxiety in iTTP patients.
Methods: We examined with validated questionnaires the prevalence of depressive (PHQ-9) and anxiety symptoms (GAD-7) in 104 iTTP patients, as well as parameters of subjective cognitive deficits (FLei), quality of life (QLQ-C30), attitude to life (LOT-R) and resilience (RS-11) at two observation points one year apart. At the second observation time, an age- and sex-matched healthy control group (n=134) was simultaneously interviewed.
Results: Survivors of acute iTTP had significantly more depressive symptoms (p< 0.001), a clear tendency to anxiety disorders (p=0.035) and a significantly worse cognitive performance (p=0.008), as compared to healthy controls. Sex, age, physical activity, and partnership status had no significant influence on depression, whereas the number of comorbidities had (diabetes mellitus, cancer, hypertension, coronary heart disease etc.). Worse scores of resilience, attitude to life and quality of life were reported by patients as compared to controls. A positive inverse correlation was found between severity of depressive symptoms and results on resilience and quality of life.
Conclusions: In summary, iTTP patients have a reduced quality of life, worse attitude to life and lower resilience than control subjects. The prevalence of depressive and anxiety disorders and disturbed physical and mental function is higher in patients than in controls. It remains to be investigated whether psychological or psychiatric counseling in these long-term patients will help to improve neuropsychiatric disturbances during long-term follow-up.
To cite this abstract in AMA style:Falter T, Boeschen S, Beutel M, Lackner K, Lämmle B, Scharrer I. Influence of Personality and Life Conditions on Depression, Anxiety and Cognitive Performance in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura (iTTP) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/influence-of-personality-and-life-conditions-on-depression-anxiety-and-cognitive-performance-in-104-patients-having-survived-acute-autoimmune-thrombotic-thrombocytopenic-purpura-ittp/. Accessed January 28, 2022.
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