Abstract Number: PB2236
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » Thrombophilia
Background: Hypercoagulability is part of the aggressive biology of cancer playing an essential role in thrombosis formation and tumor growth. Whether or not carriers of major inherited thrombophilia have a higher predisposition to cancer is still unknown.
Aims: To evaluate whether carriers of inherited defects of antithrombin, protein C or protein S exhibited a higher risk for the development of cancer as compared to non carriers.
Methods: In this prospective family cohort study we enrolled a total of 506 subjects (45% men; median age at the enrollement 38 years), belonging to 84 different kindreds.
Results: A total of 4210 and 5353 patient observation-years were considered in carriers and non-carriers, respectively. During the observation-years, sixteen tumors developed in carriers (6.7%) as compared to eighteen in non-carriers (7.7%). Overall, annual incidences of cancer were 0.4% (95% CI, 0.2 to 0.6) in carriers and 0.34% ( 95% CI 0.2 to 0.5) in non-carriers, respectively (RR, 1.0 [95% CI 0.99 to 1.0]).
Because the risk of cancer varies with age, we performed a time-dependent analysis. By considering only family members less than 60 years of age, during the observation-years, nine tumors developed in carriers (3.6%) as compared to three in non-carriers (1.2%). Overall, annual incidences of cancer were 0.2% (95% CI, 0.07 to 0.35) and 0.06% ( 95% CI 0.007 to 0.12) in carriers and non-carriers, respectively. Carriers of inherited defects less than 60 years of age showed a RR for cancer of 3.81(95% CI, 1.03 to 14.1) as compared to non-carriers.
Conclusions: In this large prospective cohort study, family members who were carriers of major thrombophilia due to clotting inherited inhibitor deficiencies presented with a higher risk of developing cancer before the age of 60 as compared to non-carriers. Further studies are needed to confirm this data.
To cite this abstract in AMA style:
Tormene D, Gavasso S, Turatti G, Simion C, Marobin M, Campello E, Simioni P. Inherited Deficiency of Antithrombin, Protein C or Protein S Is Associated with an Increased Risk of Cancer at a Younger Age [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/inherited-deficiency-of-antithrombin-protein-c-or-protein-s-is-associated-with-an-increased-risk-of-cancer-at-a-younger-age/. Accessed October 1, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/inherited-deficiency-of-antithrombin-protein-c-or-protein-s-is-associated-with-an-increased-risk-of-cancer-at-a-younger-age/