Background: One of the most significant complications of haemophilia treatment is the development of an inhibitor to exogenous factor viii administered in Haemophilia. As a result of the immune response, genetic predisposition and environmental risk factors. This usually contributes to the treatment challenge and decrease the quality of life

Aims: The aim of this study is to determine the prevalence , pattern and possible risk factors for development of Inhibitors in haemophilia A patients attending clinics in south west Nigeria

Methods: Information such as age, sex, clinical history, annual bleed rate, infusion history including types of factor replacement therapies they have been exposed to were retrieved from the World Bleeding Disorder Registry. Samples were taken and APTT based Inhibitor screening was carried out.

Results: A total of 40 haemophilia A patients were enrolled in this study , all are Male patients with age range between 2 years and 30 years of age. 75% were severe Haemophilacs, 22.5% moderate and 2.5% were mild. Fourty percent of Haemophilia A had positive inhibitor screening. 75% of those that tested positive to inhibitors had time dependent inhibitors while 25% have a pattern that appears as time independent inhibitors(likely high titre factor viii inhibitor). All the patient with inhibitors are of severe phenotype using clinical and laboratory parameters.

Conclusions: Factor vii inhibitors causes major challenge in Haemophilia management. routine screening and genetic testing can aid early identification and proper anagement plan

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/inhibitor-epidemiology-among-people-living-with-haemophilia-a-in-south-west-nigeria/