Abstract Number: VPB0616
Meeting: ISTH 2022 Congress
Background: One of the major reasons people are severely affected by COVID-19 is because of the combination of inflammation and thrombosis that they are subjected to. COVID-19 is a disorder where thrombosis and inflammation play an essential role in the pathogenesis. Several predictive interleukin markers for COVID-19 have been identified since its discovery These inflammatory markers include ( IL-1-alpha and -beta, IL-6, IL-8, IL-10 and TNF-alpha). The aim of this study was to determine the interleukin/s that are mostly affected by COVID-19 in order to make recommendation on cost-effective interleukin testing of COVID-19 patients.
Aims: The aim of this study was to determine the interleukin/s that are mostly affected by COVID-19 in order to make recommendation on cost-effective interleukin testing of COVID-19 patients.
Methods: We recruited 73 patients admitted with PCR confirmed severe COVID-19 in the COVID-19 wards at the COVID Unit of Universitas Hospitals in Bloemfontein, South Africa. The survival rate of these patients were 36%. Before testing, frozen citrated plasma samples were thawed at 37°C and assayed within 4 hours. The cytokine profile (IL-1-alpha and -beta, IL-6, IL-8, IL-10 and TNF–alpha), were measured with enzyme assay kits from Biolegend (USA).
Results: IL-10 levels were increased in all severe COVID-19 patients. Only 40% of patients present with increased IL-6 and IL-1 beta levels. IL-8 levels were increase in only 14% of patients, while only 1% of patients presented with increased IL-1-alpha and 4% with increased TNF-alpha levels. There were no correlation between increased cytokine levels and survival in the patients.
Conclusion(s): We recommend the use of only IL-10 as a marker for severe COVID-19.
To cite this abstract in AMA style:Meiring M, Nkuna V, Botes L, Smit F. Interleukins that are mostly affected in severe coronavirus disease 2019 (COVID-19) [abstract]. https://abstracts.isth.org/abstract/interleukins-that-are-mostly-affected-in-severe-coronavirus-disease-2019-covid-19/. Accessed February 27, 2024.
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