Background: Thrombophilia is a condition of hypercoagulability and has been associated with adverse pregnancy outcomes. It may be hereditary or acquired. Five to 20% of women experience one or more pregnancy loss during their reproductive age. Thrombophilia has been suggested to play a key role in recurrent pregnancy losses, yet controversy exists as to whether thrombophilia is a cause or an association. Internationally, the prevalence of hereditary thrombophilia differs among races, geographical areas, and communities.
Aims: To evaluate the role of Antithrombin, Protein C, Protein S, and Factor V Leiden in recurrent pregnancy loss and to compare the cause of hereditary thrombophilia among women with recurrent fetal loss.
Patients with two or more pregnancy loss having ages 17-45 years included in the descriptive cross-sectional study. While patients with liver disease, uterine fibroids. Cardiac disease, congenital abnormalities associated with pregnancy loss were excluded. A total of six ml of blood was taken and distributed in an EDTA tube and in sodium citrate. CBC was performed on automated CBC analyzer Sysmex CA 1000. PT, APTT were performed on Sysmex CA 600. Antithrombin screening was measured by INNOVANCE Antithrombin Kit. Protein C activity was performed by using Berichrome Protein C Kit. Protein S screened by Siemens Protein S Ac kit. Factor V Leiden was measured by using a Pro C global kit with factor V deficient plasma. Quality control and standard curves were performed as per kits instructions
In our study of sixty women with recurrent fetal loss, the mean ages were 28.1± 3.7. Among these 19 (31%) patients had Factor V Leiden. Protein C was found in 12 (20%). Whereas, Protein S was found in 3 (5%) patients. Antithrombin was not detected in any patients.
Conclusions: Our research-based on the results concludes that Factor V Leiden has a significant association with recurrent fetal loss.
To cite this abstract in AMA style:Ilyas K, Ujjan I, Bhatti B, Naz A, Abbasi S. Investigation of Hereditary Thrombophilia in Women with Recurrent Fetal Loss in LUMHS Hyderabad [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/investigation-of-hereditary-thrombophilia-in-women-with-recurrent-fetal-loss-in-lumhs-hyderabad/. Accessed August 19, 2022.
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