Abstract Number: PB2522
Meeting: ISTH 2020 Congress
Background: Deep vein thrombosis (DVT) is the formation of a blood clot within the deep vein vessels. DVT becomes fatal when it leads to pulmonary embolism (PE) causing complication such as heart attacks and strokes. During pregnancy, a hypercoagulable state is required to prevent women from haemorrhage during childbirth. Also, compression of the iliac vein and the hormonal changes makes pregnant women more susceptible to DVT. PE occurs in about 1 in 1000 pregnancies in the developed world and 4 in 1000 in the developing world, making it the leading cause of maternal death in the world. Computational models of DVT have been developed in the past, however, there have been few studies on the effects of physiological changes on DVT during pregnancy.
Aims: The aim of this study is to understand how the physiological changes during pregnancy affect the clot formation during DVT in the femoral vein.
Methods: Transient computational fluid dynamics (CFD) simulations were carried out in ANSYS Fluent (ANSYS, Lebanon, NH). A 2-D idealized vein vessel of diameter 11.84 mm and length 60 mm was used to simulate the clot formation in a healthy adult woman. This study adopted a thrombin-based continuum model to simulate DVT in the left femoral vein of a 27-year-old pregnant woman with thrombin being supplied at an injury zone 30% of the vein length and circumference. The investigation was carried out by comparing clotting patterns in a pregnant to a non-pregnant state by a parametric study of velocity, blood pressure, vein geometry, and thrombin concentration.
Results: Initial results illustrated in Figure 1 showed that the hormonal changes had the greatest effect while the reduction in velocity had the least effect on the clot size.
Conclusions: In future work, we plan to study the effect of anticoagulant medication using the model.
To cite this abstract in AMA style:Jimoh-Taiwo Q, Haffejee R, Ngoepe M. Investigation of Risk Factors of Deep Vein Thrombosis during Pregnancy Using a CFD Model [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/investigation-of-risk-factors-of-deep-vein-thrombosis-during-pregnancy-using-a-cfd-model/. Accessed February 28, 2024.
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