Abstract Number: PB0015
Meeting: ISTH 2021 Congress
Background: Capillary density rarefaction and endothelial dysfunction contribute to chronic hypoperfusion and cerebral small vessel disease. Prior animal experiments revealed spatiotemporal microvascular remodelling directing post-stroke brain reorganization.
Aims: We hypothesized that microvessel perfusion changes during acute cerebrovascular events could be reflected systemically and might be associated with platelet function.
Methods: In a prospective observational trial in vivo sublingual Sidestream Darkfield videomicroscopy was performed in twenty-one patients with acute ischemic/haemorrhagic stroke or transitory ischemic attacks within twenty-four hours after hospital admission and compared to an age- and sex-matched control group. Platelet function was assessed using multiple platelet aggregometry.
Results: Functional (3060 vs 3717/mm2, p=0.001) and perfused total (5263 vs 6550/mm2, p=0.002) capillary density was rarefied in patients when compared to healthy controls. There were significant associations between platelet count and functional (r=0.57, p=0.007) or perfused total capillary density (r=0.52, p=0.015) as well as platelet aggregation and perfused total capillary density (thrombin receptor-activating peptide 6: r=0.57, p=0.007) or capillary density ratio (arachidonic acid: r=-0.46, p=0.037; collagen: r=-0.55, p=0.012).
Conclusions: Cerebrovascular events are associated with altered systemic microvascular perfusion. Further, microvessel perfusion correlates with platelet count and function in our patient group.
To cite this abstract in AMA style:Wadowski PP, Schörgenhofer C, Rieder T, Ertl S, Pultar J, Serles W, Sycha T, Mayer F, Koppensteiner R, Gremmel T, Jilma B. Is Microvessel Perfusion Associated with Platelets in Acute Cerebrovascular Disorders? [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 1). https://abstracts.isth.org/abstract/is-microvessel-perfusion-associated-with-platelets-in-acute-cerebrovascular-disorders/. Accessed September 16, 2021.
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