Abstract Number: PB1824
Meeting: ISTH 2020 Congress
Background: Patients with inflammatory arthritis die prematurely of cardiovascular disease. Inflammation activates platelets.
Aims: To assess changes in dynamic platelet function in patients after treatment and improvement in inflammatory markers.
Methods: 20 consecutive patients with acute inflammatory episodes were recruited from a Rheumatology clinic. Following informed consent and clinical review, patients were treated per local protocol. Dynamic platelet function was measured at baseline and again after a 3-month interval once markers of inflammation had improved. The assay utilises video microscopy to measure dynamic platelet behaviour in microliters of blood perfused over VWF at arterial shear rates (1500 s-1 ). Tracking multiple individual platelets from frame to frame with motion-analysis software, the assay measures the total number of platelets 1) interacting with VWF, 2) translocating across VWF (GPIb dependent), and 3) stably adhering to the surface (αIIbβ3 dependent), and 4) the speed and distance platelets travel across VWF. Platelet parameters pre and post treatment were compared using a paired student t-test and post treatment changes
in platelet function were correlated to inflammatory disease markers by Pearson Correlation.
Results: 18 of 20 patients completed the study. Of the 18, 3 had a confirmed diagnosis of ankylosing spondylitis,
6 had psoriatic arthritis and the remaining 9 presented with sero +ve rheumatoid arthritis. Platelet adhesion decreased (p≤0.0001) with a corresponding increase in platelet motion (p≤0.005) following treatment. Tender joint count correlated with platelet adhesion (Pearson r = 0.616, p≤0.01) while CRP correlated with velocity of platelet movement (Pearson r = 0.563, p≤0.01) indicating that changes in clinical markers of inflammation were linked to changes in platelet function (figure 1).
Conclusions: Improvement in clinical markers of inflammation are associated with a corresponding change in platelet function.
To cite this abstract in AMA style:Kenny D, Dunne E, Leamy K, McCarthy G. Is Platelet Hyper-Reactivity a Modifiable Risk Factor in Inflammatory Arthritis? [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/is-platelet-hyper-reactivity-a-modifiable-risk-factor-in-inflammatory-arthritis/. Accessed May 6, 2021.
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