Abstract Number: PB2373
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » VTE Prophylaxis
Background: Patients-related risk factors combined with the type of surgery contribute to provide the individual risk for venous thromboembolism (VTE) for each patient at each intervention. Different risk assessment tools (RAM) were developed to predict the risk of a patient to develop VTE.
Aims: The purpose of this study is to validate the Caprini score in population with different orthopedic interventions.
Methods: Data from a large population-based case-control study (the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis [MEGA] study) on the etiology of venous thrombosis were used. The Caprini variables were identified for each patient in order to calculate the score. Missing data was imputed by multiple imputation. The sensibility, specificity, positive predict values (PPV) and negative predict values (NPV) were calculate to each of the Caprini score stratum.
Results: Of 4,721 cases and 5,638 controls, 263 cases and 94 controls underwent an orthopedic intervention. A total of 20,9% of the cases and 41,5% of the controls were estimated to be on the lowest group (Caprini < 5 points). The relative risk of developing VTE, calculated as OR between the Caprini stratums increases with increasing Caprini scale. Patients assigned with 9-10 points and 11 points or more shown three-fold and six-fold increased risk compared to patients with Caprini score 0-2 (OR 3.5, CI 95% 1.2-10.3; OR 6.3, CI 95% 1.7-22.9), respectively. The discrimination of the test was moderate (c-statistic: 0.64). For the cutoff of 5-6 and 7-8 points, the sensitivity was 79% and 59% and the specificity was 41% and 60%, respectively.
Conclusions: The Caprini score is a useful tool to predict the risk of VTE in orthopedic patients, with a moderate ability to discriminate the patients at risk. The prevalence of VTE in each intervention should be include in the rational to decide which patient should receive the prophylaxis.
To cite this abstract in AMA style:
Zambelli R, Nemeth B, Touw C, Rosendaal F, Rezende S, Cannegieter S. Is the Caprini Score a Reliable Tool to Predict the Risk of Venous Thrombosis in Orthopedic Patients? [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/is-the-caprini-score-a-reliable-tool-to-predict-the-risk-of-venous-thrombosis-in-orthopedic-patients/. Accessed January 28, 2022.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/is-the-caprini-score-a-reliable-tool-to-predict-the-risk-of-venous-thrombosis-in-orthopedic-patients/