Background: Platelet activation has an established role in the pathology of venous thromboembolism (VTE). The role of mean platelet volume (MPV), as a biomarker of platelets activation is not clear in the setting of VTE. Although several studies found a positive correlation between mean MPV and VTE, one recent study (the Parma study) – found a negative correlation between MPV and VTE (Lippi G, Buonocore R, Cervellin G. The mean platelet volume is decreased in patients diagnosed with venous thromboembolism in the emergency department. Semin Thromb and Hemost 2016;42:632-5).

Aims: The purpose of our study was to evaluate the role of MPV in differentiation of VTE from non-VTE, in the Emergency Department (ED), when the clinical presentation in both categories is of VTE, and to try to establish what the MPV size limits are in our hospital, when true VTE is diagnosed.

Methods: We conducted a retrospective case-controlled study of 316 VTE consecutive patients who presented to the ED of Galilee Medical Center, Nahariya, Israel. The control group was composed of 124 consecutive patients who presented to the ED with a picture of clinical VTE but without proven VTE.

Results: Higher MPV values were also found in the control group. The correlation of MPV values and VTE was examined with univariate logistic model. It was found that as MPV increases, a decrease in VTE incidence occurs (Odds ratio (OR) = 0.530, p< 0.001).

Conclusions: Statistical analysis of the acquired results indicates that MPV value cannot aid in the differential diagnosis of real VTE or in patients with VTE-like clinical picture presenting to the ED.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/is-there-a-predictive-value-of-high-mean-platelet-volume-in-early-diagnosis-of-venous-thromboembolism-in-the-emergency-department/