Background: The association of malignancies with venous thromboembolism is known but the association with arterial thromboembolism is not so clear. There is also insufficient data on the association of certain lymphoma entities with coronary artery disease (CAD).

Aims: To determine the prevalence of  CAD in different types of lymphoma.

Methods: We collected data retrospectively from patients with Hodgkin’s and non-Hodgkin’s lymphoma at the General Hospital Dr. Josip Benčević from the beginning of 2011. by August 2020.

Results: 121 patients were included in this study, 67 (55%) female. 11 (9%) patients had CAD,  8 male and 3 female. Out of a 121 patients with lymphoma, 51 (42%) had diffuse large B-cell lymphoma (DLBCL), 13 (11%) had follicular lymphoma (FL), other indolent lymphomas had 20 (17%), 13 (11%) had Hodgkin’s lymphoma, T lymphomas 6 (5%) and 18 (15%) patients had other types of lymphoma. The time from the first manifestation of CAD to the diagnosis of lymphoma ranged from 3 months to 20 years. Of the 11 patients with CAD, 7 (64%) had DLBCL, 2 (18%) small cell lymphoma, 1 (9%) hairy cell leukemia, and 1 (9%) FL. No one had CAD after lymphoma diagnosis.

Conclusions: This study suggests a higher presence of CAD in patients with DLBCL than in other types of lymphoma. The prevalence of CAD in DLBCL is almost twice as high as in the general population (6.7% for the general population older than 20 years) while for other types of lymphoma it is similar to prevalence in the general population. Interestingly in our study was higher prevalence of female with lymphoma while CAD was almost 3 times more common in male. Further studies with more patients are needed to confirm this observations and eventually to find a link between DLBCL and CAD.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/is-there-an-association-of-diffuse-large-b-cell-lymphoma-with-coronary-artery-disease/