Abstract Number: PB2502
Meeting: ISTH 2020 Congress
Background: Platelet volume indices (PVI), including mean platelet volume (MPV), platelet distribution width (PDW) and proportion of large platelets (P-CSF), are obtained using low-cost hematological analyzers. It is suggested that these indices can be used in clinical practice as markers of platelet function in women using oral contraceptives (OC) or hormonal therapy (HT).
Aims: To evaluate the association of PVI and the use (current or past) of OC and TH in a sample of Brazilian women of childbearing age or of menopause.
Methods: Cross-sectional study, carried out with 1,249 women, of childbearing age or of menopause, from the baseline (2008-2010) of the Longitudinal Study on Adult Health (ELSA-Brasil), from Minas Gerais and Rio Grande do Sul. PVI were performed on a specialized hematology analyzer, including MPV, PDW and P-LCR. All participants were questioned about the use of OC and of HT and were categorized in current users, former users and nonusers. The ANOVA test and Bonferroni post-test were used to compare means according to the categories of use of COs and HT and the value of p < 0.05 was considered significant.
Results: Participants of childbearing age had an average age of 45.1 ± 5.0 years, while those in menopause, 58.3 ± 6.5 years. No significant differences were observed in the mean values of VPM, PDW and P-LCR between non, formers and current users of OC and neither of HT.
Conclusions: No association was found neither between use of OC nor of HT (current and past) and platelet volume indexes including MPV, PDW and P-LCR. Longitudinal studies are needed to confirm our findings.
To cite this abstract in AMA style:Rios D, Resende T, Maluf C, Ribeiro AL, Carvalho MDG, Barreto S, Chor D, Aquino E, de Figueiredo R. Lack of Association between the Use of Female Hormones and Platelet Volume Indexes: Evidence from the Longitudinal Study of Adult Health (ELSA-Brasil) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/lack-of-association-between-the-use-of-female-hormones-and-platelet-volume-indexes-evidence-from-the-longitudinal-study-of-adult-health-elsa-brasil/. Accessed November 26, 2021.
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