Abstract Number: PB0026
Meeting: ISTH 2021 Congress
Background: Leo Buerger’s disease is a non-atherosclerotic arteriopathy, characterised by segmental and inflammatory obliteration affecting the small and medium-sized arteries and veins of four limbs. This pathology mainly affects young men who smoke.
Aims: To specify the clinical characteristics and the evolutionary profile of patients suffering from this condition.
Methods: A retrospective study including 13cases of Leo Buerger’s disease diagnosed over a period of 22years.The diagnosis was based on Mozes’ criteria.
Results: There were 12men and one woman, all smokers. The average age at diagnosis was39.9years. The disease is revealed by acute ischaemia of the limb in 6cases, intermittent claudication of the limb in 4cases, dry digital gangrene in 2cases and venous thrombosis in 2cases. 12patients had distal arterial ischaemia. The ischaemia unilaterally affected the lower limb in 10patients and the upper limb in4 patients. A decrease in peripheral pulses was noted in 4cases and abolition in 8cases. Trophic complications were found in 12patients, involving digital ulcerations (3cases), soft tissue infections (5cases), osteitis (3cases), distal necrosis (3cases), gangrene (1case) and sensory disturbances (2cases). Raynaud’s phenomenon was only observed in 2patients, as was superficial thrombophlebitis. Arterial echodopler, performed on 9patients, confirmed the distal location in all cases and confirmed bilateral damage in 6patients. The arteriography carried out on 2patients revealed left tibiofibulopedious stenosis in one case and distal arteritis in one case. An angioscan of the lower limbs carried out in 7patients showed distal arterial occlusions. Therapeutically, smoking cessation and local care were offered in all patients. All patients received medical treatment including one to two vasodilators and a platelet anti-aggregant. Heparin therapy was prescribed for 4patients.Surgery was necessary in 8patients. The evolution was favourable in 6cases. A recurrence of digital ischaemia was observed in 2cases.
Conclusions: Leo Buerger’s disease is a rare condition with difficult diagnosis to confirm due to the lack of specific markers.
To cite this abstract in AMA style:Chabchoub I, Ben Salah R, Regaieg N, Frikha F, Bahloul Z. Leo Buerger’s Disease: About 13 Cases [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/leo-buergers-disease-about-13-cases/. Accessed December 7, 2021.
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