Abstract Number: PO0015
Meeting: ISTH 2022 Congress
Theme: COVID and Coagulation » COVID and Coagulation, Clinical
Background: CoagulopathyandthromboemboliceventsareamongthecomplicationsofCoronaVirus disease2019(COVID-19).Abnormal coagulation parameters in COVID-19patientsare important prognostic factors of disease severity
Aims: To analyze coagulation profilesofhospitalizedCOVID-19patientsin Addis Ababa, Ethiopia, the Horn of Africa.
Methods: Thisprospectivecross-sectionalstudywasconductedamong455Covid-19patientsadmittedatMillenniumCOVID 19careandtreatmentcenter,AddisAbaba,EthiopiafromJuly1-October23,2020.ProthrombinTime(PT),Activated Partial Thromboplastin Time(APTT) and Internationalnormalizedratio(INR)weredeterminedonHUMACLOTDUEPLUS®coagulationanalyzer(Wiesbaden,Germany).Inallstatisticalanalysisofresults,p < 0.05 wasdefinedasstatisticallysignificant.
Results: Aprolongedprothrombintimewasfoundin 46.8%ofstudyparticipantswithCOVID-19and aprolongedprothrombintimeandelevatedINRin 53.3%ofstudysubjectswithsevereand51%ofcriticallyCOVIDpatients.Thrombocytopeniawasdetectedin 22.1%ofCOVID-19 patients.50.5%and51.3%ofCOVID-19patientsolderthan55yearshadthrombocytopeniaandprolongedAPTTrespectively
Conclusion(s): Inthisstudy,prolongedprothrombintimeandelevatedINRweredetectedinmorethan50% ofsevereandcriticalCOVID-19patients.ThrombocytopeniaandprolongedAPTTweredominantin COVID-19patientsolderthan55years.Thus,werecommendemphasistobe givenformonitoringofplateletcount,PT,APTTandINRinhospitalizedandadmitted COVID-19patients.
To cite this abstract in AMA style:
Tsegay Y, Bitew M. Level of coagulation aberrations among COVID-19 patients in Ethiopia, Findings from the Horn of Africa [abstract]. https://abstracts.isth.org/abstract/level-of-coagulation-aberrations-among-covid-19-patients-in-ethiopia-findings-from-the-horn-of-africa/. Accessed September 27, 2023.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/level-of-coagulation-aberrations-among-covid-19-patients-in-ethiopia-findings-from-the-horn-of-africa/