Abstract Number: PB1721
Meeting: ISTH 2020 Congress
Background: Obesity is associated with a pro-inflammatory and pro-thrombotic state that supports atherosclerosis progression and platelet hyperreactivity. During the last decade, the platelet lipidome has been consider a treasure trove as a source of biomarkers for preventing and treating different pathologies.
Aims: The main goal of the present study was to determinate the lipid profile of platelets from morbid obese patients compared with their age- and sex-matched controls.
Methods: Lipids from washed platelets were extracted and major phospholipids, sphingolipids and neutral lipids were analyzed by LC and GS couple to mass spectrometry.
Results: According to the data, the platelet membrane cholesterol levels were significantly downregulated in the obese group and triglycerides increased. Cholesterol and triglycerides levels are known to impact on platelet membrane fluidity, which may lead to microviscosity alterations, and in turn on platelet activation and aggregation. Furthermore, the levels of ceramide and sphingomyelin were decreased in platelets from obese individuals.
Conclusions: We will discuss our lipid profiling results in the context of the hyperactivate platelet state in obese individuals and the atherothrombotic risk in obesity.
To cite this abstract in AMA style:Nuñez Barrachina M, Chicanne G, Bertrand-Michel J, Pardo M, Payrastre B, García Á. Lipidome Profile in Platelets from Obese Patients: New Assistances of Platelet Dysfunction in Obesity [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/lipidome-profile-in-platelets-from-obese-patients-new-assistances-of-platelet-dysfunction-in-obesity/. Accessed November 27, 2021.
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