Abstract Number: PB0123
Meeting: ISTH 2020 Congress
Background: Much evidence suggests that brain ischemia inducts an unrestrained inflammation that starts within a few minutes and remains for a few days after an ischemic stroke. Hence, the antioxidant and anti-inflammatory agents may be practical providing protection from neurological damage caused by stroke. Currently, there is a lack of approved therapies that are able to reduce infarct size or neurological disability following a stroke. One of the approaches that may limit the damage after a stroke is prophylactic treatment. It is worth mentioning that thromboembolism is the second leading cause of death in patients with cancer.
Aims: This study was designed to investigate whether liquorice or sumac are effective in a thromboembolic model of stroke in rats.
Methods: Stroke was induced in rats by middle cerebral artery occlusion using an autologous pre-formed blood clot. Liquorice solution (150 mg/kg) or sumac extract solution (250 mg/kg) was injected intraperitoneally to each rat of the seven-member groups for 7 subsequent days prior to stroke induction. Behavioral scores, infarct size, and brain edema, as well as the level of tumor necrosis factor-alpha, malondialdehyde, glutathione, and catalase activity, and also superoxide dismutase activity were determined in the ipsilateral cortex 24 hours following the stroke induction. The control group received normal saline and a similar protocol was carried out.
Results: Liquorice (150 mg/kg) and sumac extract (250 mg/kg) for 7 days, statistically similar to each other, but different to normal saline, curtailed brain infarction and edema, improved behavioral scores and prevented enhanced oxidative stress and tumor necrosis factor-alpha level in the ischemic brain tissue.
Conclusions: Since liquorice and sumac have been documented as two powerful antioxidant, anti-inflammatory, and antithrombotic agents, the observed effects may be justifiable. Future studies of possible mechanisms could provide novel therapeutic strategies in clinical stroke, especially in patient with cancer receiving chemotherapy medications.
To cite this abstract in AMA style:Parsa A, Majidian R, Abasi S, Modjtahedi F, Babaeian M. Liquorice and Sumac Attenuate Brain Damage Caused by Ischemic Stroke in Rat [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/liquorice-and-sumac-attenuate-brain-damage-caused-by-ischemic-stroke-in-rat/. Accessed May 6, 2021.
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