Abstract Number: PB0192
Meeting: ISTH 2021 Congress
Background: Antiphospholipid antibodies (APA) clinical relevance in COVID-19 is controversial.
Aims: We aimed to investigate the prevalence and prognostic value of conventional and non-conventional APA in COVID-19 patients.
Methods: This study was a multi-centric, prospective observational French cohort of patients hospitalized for COVID-19 suspicion.
Results: 249 patients were hospitalized for suspected COVID-19, including 154 (61.8%) with confirmed COVID-19 and 95 (38.2%) not confirmed. We found a significant increase in lupus anticoagulant (LA) positivity among COVID-19 positive patients (60.9% versus 23.7% in non-COVID19 patients, p<0.001), while prevalence of conventional (LA, IgG, IgM and IgA isotypes) and non-conventional APA (anti-phosphatidylserine/prothrombin IgG and IgM) were low in both groups. COVID-19 patients with LA positivity had higher levels of fibrinogen (6.0 g/L, IQR 5.0–7.0 versus 5.3 IQR 4.3–6.4, p=0.028) and C-reactive protein (CRP, 115.5 IQR 66.0–204.8 versus 91.8 mg/L, IQR 27.0–155.1, p=0.019). Univariate analysis did not show any association between LA positivity and higher risk of venous thromboembolism (VTE, OR 1.02, 95% CI 0.44-2.43, p=0.95) or in-hospital mortality (OR 1.80, 95% CI 0.70–5.05, p=0.24). Unadjusted and adjusted (to CRP, age and sex) Kaplan-Meier survival curves according to LA positivity confirmed the absence of association with VTE or in-hospital mortality (unadjusted: p=0.64 and p=0.26, respectively; adjusted: hazard ratio = 1.13 95% CI 0.48–2.60 and 1.80 95% CI 0.67–5.01).
Conclusions: COVID-19 patients have an increased prevalence of LA positivity associated with biological inflammation markers. However, positive LA at admission is not associated with VTE risk and/or in-hospital mortality.
To cite this abstract in AMA style:Gendron N, Dragon-Durey M-, Chocron R, Darnige L, Jourdi G, Philippe A, Hadjadj J, Duchemin J, Khider L, Yatim N, Mauge L, Gaussem P, Samama CM, Planquette B, Sanchez O, Diehl JL, Mirault T, Fontenay M, Terrier B, M Smadja D. Lupus Anticoagulant Positivity is Not Associated with Venous Thromboembolism or In-hospital Mortality In COVID-19 [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/lupus-anticoagulant-positivity-is-not-associated-with-venous-thromboembolism-or-in-hospital-mortality-in-covid-19/. Accessed December 5, 2021.
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