Background: Mondor’s disease is a rare entity including superficial thrombophlebitis located in the thoracoabdominal wall. It is usually a benign condition but it can reveal a neoplastic lesion or a thrombophilia.

Aims: The aim of this study is to present two unusual etiology of Mondor´s disease.

Methods: Two new cases are presented.

Results: A-39-year-old male patient followed for acute articular rheumatism was hospitalized for thrombosis of the right thoraco-epigastric vein. There was no thoracic trauma, a heavy load, or an intense physical effort. The examination of the breasts, the thoracic radiography and the abdominal-pelvic ultrasound were normal. The digestive endoscopy showed only a gastritis. Biology showed a decreased rate of antithrombin III. The decision was to treat the patient by Vitamin K antagonist (VKA) for prolonged duration.
A 69-year-old patient with diabetes and hypertension was hospitalized for thrombosis of superior epigastric vein. Constitutional thrombophilia screening was negative.
The mammography was normal. The thoraco-abdominal CT-Scan showed an agenesis of the lower vena cava. The patient was treated with heparin VKA and a local treatment. The abdominal thrombophlebitis decreased within 6 weeks.

Conclusions: Mondor’s disease affects more frequently women than men. To our knowledge, only 50 male cases were reported. The peculiarities of our observations reside in the occurrence of the disease in a man and that it was a manifestation of even less frequent condition such as Inferior vena cava agenesis and Antithrombin III deficiency.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/mandors-disease-a-manifestation-of-rare-conditions/