Abstract Number: VPB1419
Meeting: ISTH 2022 Congress
Background: Women with a history of severe preeclampsia (PE) are at high risk of disease recurrence, which is realized in 10-25% of women. Taking into account the theory of pathogenesis of PE, the study of circulating biomarkers of endothelial dysfunction, such as endothelin-1 (ET-1) and endothelial microvesicles (EVs), looks promising.
Aims: To study the role of endothelial dysfunction markers in predicting the recurrence of early preeclampsia.
Methods: A prospective randomized observational study was conducted including 127 women with a history of severe early PE. The inclusion point is the preconception period (PC). The endpoint is delivery, the surrogate points – the level of ET-1 (pmol/ml) and endothelial EVs at the PC period and at 11-12, 19-21 and 27-28 weeks of gestation. Before the end of the study, 30 patients were excluded from the study according to the inclusion/exclusion criteria. The remaining 97 patients were randomized into 2 groups according to the observed pregnancy outcomes: one with a beneficial gestation course and delivery at term (control group, n=59) and another one with recurrent severe PE in the present pregnancy (main group, n=38).
Results: The study at the PC period showed that the median (Me) of ET-1 level was Me=0.55 [95%CI:0.39-0.90] in the main group versus Me=0.40 [95%CI:0.27-0.65] in the control group (p=0.0382). The same data were obtained in the study of endothelial EVs, the level of which was significantly higher in women with realized PE, in relation to the control group: Me=21.8 [95%CI:20.2-32.6] and Me=14.5 [95%CI:13.4-17.3] (p=0.0021), respectively.
The ROC analysis showed that the level of endothelin> 0.514 (AUC-0.609; 95%CI:0.559-0.745), as well as the level of endothelial EVs> 1.71 (AUC-0.648; 95%CI:0.453-0.813) had a predictive ability of moderate strength.
Conclusion(s): The findings seem to be a background for the use of biomarkers of endothelial dysfunction as a prognostic predictor of recurrent PE starting from the PC period.
To cite this abstract in AMA style:Nikolaeva M, Momot A, Terekhina V, Kudinov A. Markers of endothelial dysfunction as predictors of recurrent severe preeclampsia [abstract]. https://abstracts.isth.org/abstract/markers-of-endothelial-dysfunction-as-predictors-of-recurrent-severe-preeclampsia/. Accessed October 1, 2023.
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