Abstract Number: PB1697
Meeting: ISTH 2020 Congress
Theme: Platelets and Megakaryocytes » Platelet Function and Interactions
Background: Platelets play a critical role in the development of cardiovascular disease (CVD), and type 2 diabetes is a major risk factor for CVD. Despite this, evidence in large populations on the role of platelet biomarkers in diabetes remains limited.
Aims: We investigated the association of diabetes with platelet aggregation in response to multiple agonists or mean platelet volume in cross-sectional and prospective studies.
Methods: Multivariable linear mixed effect models were used to determine associations in the Framingham Heart Study (n=3,244 individuals, n=244 diabetics at baseline) between metabolic syndrome and/or diabetes and platelet aggregation, and the association of mean platelet volume (MPV) with diabetes was assessed by multivariable linear analysis in the UK BioBank cohort (n=463,703, n=36,297 diabetics).
Results: Contrary to the hypothesis, lower platelet aggregation was associated with prevalent diabetes in most agonists with the exception of a low concentration of epinephrine (0.1µM) and only after data were stratified by male sex and/or metabolic syndrome. After a median of 18.1 years follow-up, no platelet aggregation trait was associated with increased risk of diabetes (n=344). However, increased MPV was significantly associated with diabetes (β=0.0976; P=8.62×10-33). Interestingly, sex-stratified analyses indicated the association of MPV with diabetes is markedly stronger in males (β=0.1232; P=1.00×10-31) than females (β=0.0514; P=7.37×10-5). Increased MPV was associated with insulin (β=0.1341; P=1.38×10-11) but decreased MPV was associated with both metformin (β=-0.0763; P=1.99×10-6) and the sulphonylureas (β=-0.0559; P=0.0034). These diabetic medications showed the same direction of effect in both sexes, however the association strength with MPV nearly doubled in women compared to men.
Conclusions: Platelet function as measured by aggregation to ADP, collagen or epinephrine is not consistently associated with diabetes, however, MPV is robustly associated. Future work may focus on how MPV segments pre-diabetics, diabetics, and diabetes drugs for risk prediction.
To cite this abstract in AMA style:
Chan MV, Rodriguez BAT, Lachapelle A, Wallace de Melendez C, Armstrong PC, Chen M-, Warner TD, Johnson AD. Mean Platelet Volume, and Not Platelet Aggregation, Is Associated with Diabetes: Population Studies from 3,000 to 463,000 Individuals [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/mean-platelet-volume-and-not-platelet-aggregation-is-associated-with-diabetes-population-studies-from-3000-to-463000-individuals/. Accessed April 26, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/mean-platelet-volume-and-not-platelet-aggregation-is-associated-with-diabetes-population-studies-from-3000-to-463000-individuals/