Abstract Number: PB2533
Meeting: ISTH 2020 Congress
Background: Platelets play a critical role in both hemostasis and thrombosis. Mean platelet volume (MPV) is a potential biological marker of platelet function. Higher MPV was shown to be associated with traditional cardiovascular risk factors such as diabetes, obesity, hypertension and hypercholesterolemia and is associated with an increased risk for both arterial and venous thrombosis. However, there is currently no report linking MPV to pregnancy or pregnancy loss.
Aims: To define the change of MPV from adolescent to adult and throughout pregnancy.
Methods: We evaluated MPV and platelet counts from adolescent to adult throughout pregnancy in women who delivered at Tongji University Shanghai Tenth People’s Hospital between Jan 1, 2017 and December 31, 2018. These MPV and platelet counts were compared with those of nonpregnant women who were included in Tongji University Shanghai East People Hospital from June 1, 2017 to September 30, 2019.
Results: Among the 314 deliveries that occurred during the study period, 258 women had sufficient data for our analyses. Among them the median MPV at the 12th week of gestation, 9.20 fL, was significantly lower than that in the 13,1261 nonpregnant women, 10.50 fL (P< 0.001), with a decrease by 12.4%. Then the MPV gradually increased until delivery by 21.3%. By contrast, mean platelet counts decreased by an estimated 23.8% during pregnancy. In adulthood, MPV kept constantly stable while platelet counts gradually decrease (female:11.8%, male:17.0%) regarding to age in adults. Contrast to the steady pattern of MPV in adult men and nonpregnant women, there was a sudden fall of MPV in late adolescent, no matter female or male.
Conclusions: MPV keeps stable in adults while decreased in late adolescent and early in the first trimester during pregnancy.
To cite this abstract in AMA style:Xu Y, Zhou J, Shao X, Wang D, Xiang Y. Mean Platelet Volume from Adolescent to Adult and during Pregnancy [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/mean-platelet-volume-from-adolescent-to-adult-and-during-pregnancy/. Accessed November 29, 2021.
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