Abstract Number: PB2203
Meeting: ISTH 2020 Congress
Background: We recently proposed the post-VTE functional status (PVFS) scale for assessment of patient-relevant functional limitations following an episode of venous thromboembolism (VTE).
Aims: To further develop this PVFS scale.
Methods: Guided by the input of VTE experts and patients, we refined the PVFS scale and its accompanying manual, and attempted to acquire broad consensus on its use. We also quantified the reproducibility of PVFS scale assessment.
Results: A Delphi analysis was performed involving 53 international VTE experts with diverse scientific and clinical backgrounds. In this process, the number of scale grades of the originally proposed PVFS scale was reduced, and descriptions of the grades were improved. After these changes, a consensus was reached on the number/definitions of the grades (Table 1), and method/timing of the scale assessment (Figure 1). The relevance and potential impact of the scale was confirmed in three focus groups totaling 18 VTE patients, who suggested additional changes to the manual, but not to the scale itself. Using the improved manual, the κ-statistics between the PVFS scale self-reporting and its assessment via the structured interview was 0.75 (95%CI 0.58-1.0), and 1.0 (95%CI 0.83-1.0) between independent raters of the recorded interview of 16 focus groups members.
Conclusions: We improved the PVFS scale and demonstrated broad consensus on its relevance, optimal grades, and methods of assessing the PVFS scale among international VTE experts and patients. We improved the PVFS scale and its manual. The interobserver agreement of scale grade assignment was shown to be good-to-excellent. The PVFS scale may become an important outcome measure of functional impairment for quality of patient care and in future VTE trials.
|PVFS scale grade||Description|
|0: No functional limitations||All usual duties/activities at home or at work can be carried out at the same level of intensity. Symptoms, pain and anxiety are absent.|
|1: Negligible functional limitations||All usual duties/activities at home or at work can be carried out at the same level of intensity, despite some symptoms, pain, or anxiety.|
|2: Slight functional limitations||Some usual duties/activities at home or at work are carried out at a lower level of intensity or are occasionally avoided due to symptoms, pain, or anxiety.|
|3: Moderate functional limitations||Usual duties/activities at home or at work have been structurally modified (reduced) due to symptoms, pain, or anxiety.|
|4: Severe functional limitations||Assistance needed in activities of daily living due to symptoms, pain, or anxiety: nursing care and attention are required.|
|D: Death||Death occurred before the scheduled assessment.|
|Full manual for structured interview and patient self-report is available. Providing a reference value (pre-VTE grade) is optional and should refer to the functional status 1 month prior to the VTE diagnosis.|
[Table 1: Final post-VTE functional status scale as agreed upon by the Delphi panel and patient focus groups]
To cite this abstract in AMA style:Boon GJAM, Barco S, Bertoletti L, Ghanima W, Huisman MV, Kahn SR, Noble S, Prandoni P, Rosovsky RP, Sista AK, Siegerink B, Klok FA. Measuring Functional Limitations after Venous Thromboembolism: Optimization of the Post-VTE Functional Status (PVFS) Scale [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/measuring-functional-limitations-after-venous-thromboembolism-optimization-of-the-post-vte-functional-status-pvfs-scale/. Accessed January 21, 2022.
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