Abstract Number: PB0959
Meeting: ISTH 2021 Congress
Background: Increase in mean platelet volume (MPV) was related as an indicator of spinal recovery in post-chemotherapy patients, however the behavior of this parameter in patients undergoing bone marrow transplantation (BMT) is unknowed.
Aims: To evaluate if there is an association between platelet volume mean and estimated time of platelet engraftment in patients undergoing BMT.
Methods: A retrospective cohort study was carried out in 40 patients transplanted in our hospital between November 2019 and December 2020. it was determined MPV and platelet count using a counter by impedance for each patient, starting the day transplant (D0) and then every 72 hours until engraftment platelet, defined as count> 20,000 / ml and transfusion independence by 7 days. In the statistical analysis t test and Spearman’s coefficient was used.
Results: 80% of the patients received autologous transplantation and 20% allogeneic transplantation; 52% were men. The overall mean age was 51 years (range: 23 to 75). Pathologies that required transplantation were: Multiple myeloma 43%, lymphomas 37% and acute lymphoblastic and myeloid leukemia 20%. A significant difference was observed (p <0.0001, Student’s t) between the average MPV of D0 and the day of engraftment (9.6 + 0.9 vs 11.2 + 1.2, mean and SD). In 70% (95% CI 0.55 – 0.84), MPV was maximum during or in the 72 hours prior to engraftment. A correlation was observed between the difference obtained from VPM to engraftment vs D0 (DVPM), with the period time elapsed from D0 of transplantation to platelet engraftment, taking into account the following DVPM values: 1.07 (6-8 days), 1.27 (9-11 days), 1.59 (12-14 days), 2.6 (15-17 days) and 3.2 (18-20 days), all with statistical significance (p <0.01, Spearman).
Conclusions: The results found in our sample, reported that there is a relationship between the MPV and platelet engrafment in post BMT patients.
To cite this abstract in AMA style:Avila Rueda JA, Duboscq C, Ceresetto J, Palmer S, Oliveros K, Rivarola S, Cantillo AM, Carreras M, Zapata L, Sernaque MC, Flegler N, Oscar Rabinovich OR, Shanley C, Quarchioni M, Bullorsky E, Stemmelin G. Medium Plate Volume as a Predictor of Plate Engraftment Time in Patients with Bone Marrow Transplant [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/medium-plate-volume-as-a-predictor-of-plate-engraftment-time-in-patients-with-bone-marrow-transplant/. Accessed December 7, 2021.
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