Abstract Number: PB0909
Meeting: ISTH 2022 Congress
Theme: Venous Thromboembolism » Cancer Associated Thrombosis
Background: The cancer is associated to a state of hypercoagulability which can be the cause of venous thromboembolism (VTE) representing an undeniable cause of morbidity and mortality. Nevertheless, the pathophysiology of thrombi formation has not yet been fully elucidated and large variations of the risk have been demonstrated related to cancer characteristics, to the patient itself or to treatment.
Aims: In order to predict the risk of VTE in our patients, we conducted a prospective cohort study in cancer patients who will receive chemotherapy.
Methods: First, we evaluated the risk of cancer-related VTE by hypercoagulability parameters (D-dimers, microparticles, V Leiden mutation).
In a second step, we tested the predictive value of the Khorana risk score (KRS) of cancer- related VTE. Then, we developed and tested the predictive value of an expanded score based on the addition of predictive biomarkers to the KRS parameters.
Results: 165 patients were included in our study. After an observation period of 2 years, 10 patients (6.0%) developed a VTE. Among the criteria studied, only the D-dimers and the microparticles were predictive of VTE in cancer.
We validated the Khorana risk score in our study population. The positive predictive value (VPP) of this score was 13,6% and the negative predictive value (VPN) was 97,9%. After adding 2 predictive biomarkers (D-dimers and microparticles), the expanded score had a PPV of 23,5% and a VPN of 98,6%. An increased score ≥to the cut-off value of 4 set by a ROC curve was associated with a higher risk of VTE (HR = 8.753, 95% CI [2.348-32.629]).
Conclusion(s): The addition of biomarkers to the routine clinical and biological parameters of the Khorana score enhances the predictive potential of VTE risk in cancer. This will allow a better stratification of patients according to the risk of VTE with the aim of optimizing thromboprophylaxis.
To cite this abstract in AMA style:
CHEKKAL M, YAFOUR N, ELHORRI M, SAADI OUSLIM A, ADDA A, ZMOULI N, Bennaoum M. Microparticles and D-Dimers improve prediction of chemotherapy- associated thrombosis in cancer patients [abstract]. https://abstracts.isth.org/abstract/microparticles-and-d-dimers-improve-prediction-of-chemotherapy-associated-thrombosis-in-cancer-patients/. Accessed September 29, 2023.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/microparticles-and-d-dimers-improve-prediction-of-chemotherapy-associated-thrombosis-in-cancer-patients/