Abstract Number: PB0974
Meeting: ISTH 2021 Congress
Background: Inflammatory bowel diseases (IBD) are associated with a violation of the platelets properties and the hemostatic system. The effect of hyperbaric oxygenation (HBO) on these abnormalities in pediatric IBD has not been previously studied.
Aims: To evaluate platelet aggregation and the state of the hemostatic system in children with IBD and the effect of HBO on these parameters.
Methods: The study involved 27 patients aged 6 to 17 years. The study was approved by the local ethics committee of the PRMU, as well as informed consent to participate in the study. The platelet aggregation was studied in artificial shear flow on a device designed according to the principle of Schmid-Schönbein et al. (1975) modified by Levin et al. (2006). The content of soluble fibrin-monomer complexes (SFMC) was determined by the orthophenanthroline method. Similar indicators were studied after a course of HBO performed of 5-8 daily sessions in the mode of 1.3 ata for 40 minutes. The data is presented as the mean ± standard error. The results of the study were compared with similar indicators of 35 healthy children and processed by the Mann-Whitney test and Wilcoxon pair comparisons. The differences were considered statistically significant at p<0.05 and p<0.001.
Results: In children with IBD a significant increase of platelet aggregation was revealed (table 1). The number of SFMC in these patients also significantly exceeded the control values (table 2). After a course of HBO platelet aggregation decreases to the control values (table 1). There was a tendency to reduce the level of SFMC in children with IBD after the course of HBO (table 2).
Conclusions: IBD in children is characterized by a significant increase of the platelet aggregation and SFMC. The use of HBO in the treatment of IBD contributes to a pronounced and significant decrease in these indicators.
To cite this abstract in AMA style:Popovicheva A, Martusevich A, Fedulova E, Neshchetkina I. Modification of Platelet Characteristics and Hemostasis in Children with Inflammatory Bowel Diseases under Hyperbaric Oxygenation [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/modification-of-platelet-characteristics-and-hemostasis-in-children-with-inflammatory-bowel-diseases-under-hyperbaric-oxygenation/. Accessed December 6, 2023.
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