Abstract Number: VPB1379
Meeting: ISTH 2022 Congress
Background: Adherence to warfarin therapy is relevant in clinical practice due to the great variability in dose-response and the risk of complications. To date, there are no instruments for multi-dimensional assessments of warfarin therapy validated in Brazilian Portuguese.
Aims: To describe the process of development the instrument focused on a multi-dimensional assessment of adherence to warfarin therapy.
Methods: The elaboration of the instrument entitled “Questionnaire for the evaluation of multi-dimensional adherence to warfarin therapy” followed these stages: i) conceptual map; ii) preliminary version of the instrument; iii) analysis performed by judges; iv) semantic analysis of the items through a pre-test with 30 patients. The quantitative analysis was performed by calculating the Content Validity Coefficient (CVC) for the instruction and for each item.
Results: Six judges assessed the content validity and a sample of 30 patients participated in the pre-test. Of the initial 35 items, 14 were removed and 19 were modified, resulting in 21 items in the final version of questionnaire. The CVC calculation was 0.7, demonstrating that the items are relevant. The domains and their number of related items were: self-care related to warfarin therapy (7); health monitoring (4) and administration of pills (10). Approximately 77% of the patients completely understood all the items. The semantic analysis indicated the need to modify three of the 21 items of the scale. The changes involved inclusion and modification of alternatives and inclusion of terms in the wording.
Conclusion(s): The development process of the multi-dimensional instrument to assess adherence to warfarin followed the internationally recommended steps and was successfully carried out. The results obtained showed that the instrument has adequate content validity, with good acceptance and understanding of the items by the patients. It is recommended that the psychometric properties of the developed instrument be evaluated to ensure its validity and reliability to achieve the proposed objectives.
To cite this abstract in AMA style:Sousa Vianna M, Praxedes M, Afonso Reis I, Silvina Pagano A, Barbosa Ferreira C, Costa Viana R, Vieira Nascimento D, Parreiras Martins M. Multi-dimensional instrument assessment of adherence to warfarin therapy: methodological study [abstract]. https://abstracts.isth.org/abstract/multi-dimensional-instrument-assessment-of-adherence-to-warfarin-therapy-methodological-study/. Accessed February 27, 2024.
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