Abstract Number: PB0019
Meeting: ISTH 2020 Congress
Background: Coagulopathy in myocardial infarction with normal coronary arteries can reach 36% of cases.
Aims: We aimed to report a new case of a combined coagulopathy in a patient with myocardial infarction.
Methods: Case report.
Results: We report the case of a 62 year-old-male patient who was admitted for acute coronary syndrome without ST elevation and with high Troponin level. He had no history of diabetes, hypertension or tobacco. Coronary angiography revealed completely normal coronary arteries without narrowing. 1 week later he presented a second episode of myocardial infarction spontaneously reperfused. Coronary artery thrombosis was suspected and an extensive work-up for thrombophilia revealed hyperhomocysteinemia at 47 µmol/l associated to activated protein C resistance. The patient was treated with oral anticoagulation and susbtitutional treatment of folic acid with a good outcome 1 year after discharge. Controlled homocysteinemia was at 18 µmol/l.
Conclusions: Thrombophilia should be considered in patients with myocardial infarction with normal coronary arteries without apparent cardiovascular risk factors. Combined thrombophilia may expose to an increased risk for thrombosis.
To cite this abstract in AMA style:Kechida M, Jomaa W, Ben Hamda K, Klii R, Hammami S, Khochtali I, Maatouk F, Sassi M. Myocardial Infarction as a First Symptom of Activated Protein C Resistance Associated to Hyperhomocyteinemia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/myocardial-infarction-as-a-first-symptom-of-activated-protein-c-resistance-associated-to-hyperhomocyteinemia/. Accessed August 15, 2022.
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