Abstract Number: PB0132
Meeting: ISTH 2021 Congress
Theme: Coagulation and Natural Anticoagulants » Regulation of Coagulation
Background: In many plants, апticoagulants of different nature (heparin-like, peptides) have been found.
Aims: To study the possibility of displaying synergistic effects on the anticoagulant activity of the extract from the roots of the peony “Ivan Gorozhankin”, which was created by crossing the peobies “Lactiflora” and “Medicinal”, in a comparative aspect with peony “Lactiflora”.
Methods: A method for obtaining extracts from the roots of peonies “Ivan Gorozhankin” and “Lactiflora” has been developed. The anticoagulant activity of the extracts was determined in comparison with the standard low-molecular-heparin (LMH) of the Celsus company (USA) according to tests: the APTT, prothrombin time (PT) and thrombin time (TT).
Results: It was shown that extracts from both peony preparations had anticoagulant activity, but to different degrees. The anticoagulant activity of the extract from the peony “Lactoflora” corresponded to the same activity of the standard LMH. In extracts from the peony “Ivan Gorozhankin”, synergistic effects were noted, namely, an excess of APTT by 20-30%, PT – by 5-7 % and TT-by 18-20% compared to those observed in extracts from the peony “Lactiflora” at concentrations from 10-1 -10-4 mg/ml., Possible mechanisms of the activating effect of the extract from peony “ Ivan Gorozhankin” on the anticoagulant properties of plasma were considered. This is due to the blockade of the activity of the thrombin and factors of the internal mechanism of blood clotting. According to the biochemical method, the presence of a heparin-like substance in the extract from the peony “Ivan Gorozhankin” was first detected.
Conclusions: For the first time, the ability of the extract from the peony “Ivan Gorozhankina” to show synergistic anticoagulant effects exceeding those of the extract from the peony “Lactiflore” was established. On the basis of the obtained data, there is a need to study the peony “Ivan Gorozhankin” as an antithrombotic, and possibly antiatherosclerotic agent
To cite this abstract in AMA style:
Lyapina M, Kalugina M. Natural Anticoagulants from Peonies [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/natural-anticoagulants-from-peonies/. Accessed December 1, 2022.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/natural-anticoagulants-from-peonies/