ISTH Congress Abstracts

Official abstracts site for the ISTH Congress

MENU 
  • Home
  • Congress Archive
    • ISTH 2021 Congress
    • ISTH 2020 Congress
  • Resources
  • Search

Normal Values in Thrombin Generation Parameters in Hemorraghic Diseases

I. Tirado1, N. Vilalta1, L. Romero1, C. Vallvé1, I. Gich2, J.C. Souto1, J. Mateo1

1Hospital de la Santa Creu i Sant Pau. Servei d'Hematologia. Unitat d'Hemostàsia i Trombosi, Barcelona, Spain, 2Hospital de la Santa Creu i Sant Pau. Servei d'Epidemiologia, Barcelona, Spain

Abstract Number: PB0352

Meeting: ISTH 2021 Congress

Theme: Diagnostics and OMICs » Laboratory Diagnostics

Background: Thrombin Generation (TG) assay is a comprehensive test that assesses thrombin formation during the coagulation process.  ST-Genesia® is an automated system (STG, Diagnostica Stago) which provides a normalization of TG parameters against reference plasma in order to reduce technical variability.

Aims: To determine normal values for bleeding conditions with STG-BleedScreen® (STG-BLS) test in a healthy population.

Methods: We tested: 44 healthy individuals: 19 women and 25 men aged between 22 and 85 years.  STG-BLS test was performed with ST-Genesia® system. Parameters:  Lag time (ratio), peak high (%), time to peak (ratio), endogenous thrombin potential (ETP, %), velocity index (Vel %) and start tail (ratio) were analysed in absolute and normalized units.  Normal reference intervals for STG-BLS parameters were calculated for all individuals and by sex and age (<50 and ≥ 50 years).

Results: Table 1. Normalized Bleedscreen parameters
Table 1 shows all normalized parameters. Although the variables do not show a normal distribution, mean values were similar to median values. Normalized variables showed lower variability than absolute values. In women aged <50, higher values were observed for peak height and ETP (figure 1).

Figure 1. Peak height (blue) and ETP (red) by sex and age group.

Conclusions: We found differences in Bleedscreen parameters according age and sex, for this reason we consider to establish normal values, subgroups of age and sex have to be taken into account.

To cite this abstract in AMA style:

Tirado I, Vilalta N, Romero L, Vallvé C, Gich I, Souto JC, Mateo J. Normal Values in Thrombin Generation Parameters in Hemorraghic Diseases [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/normal-values-in-thrombin-generation-parameters-in-hemorraghic-diseases/. Accessed May 16, 2022.

« Back to ISTH 2021 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/normal-values-in-thrombin-generation-parameters-in-hemorraghic-diseases/

Simple Search

Supported By:

Bristol Myers Squibb and Pfizer

ISTH 2021 Congress site

Visit the official web site for the ISTH 2021 Virtual Congress »

  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2022 John Wiley & Sons, Inc. All Rights Reserved.
Wiley