Abstract Number: PB0352
Meeting: ISTH 2021 Congress
Background: Thrombin Generation (TG) assay is a comprehensive test that assesses thrombin formation during the coagulation process. ST-Genesia® is an automated system (STG, Diagnostica Stago) which provides a normalization of TG parameters against reference plasma in order to reduce technical variability.
Aims: To determine normal values for bleeding conditions with STG-BleedScreen® (STG-BLS) test in a healthy population.
Methods: We tested: 44 healthy individuals: 19 women and 25 men aged between 22 and 85 years. STG-BLS test was performed with ST-Genesia® system. Parameters: Lag time (ratio), peak high (%), time to peak (ratio), endogenous thrombin potential (ETP, %), velocity index (Vel %) and start tail (ratio) were analysed in absolute and normalized units. Normal reference intervals for STG-BLS parameters were calculated for all individuals and by sex and age (<50 and ≥ 50 years).
Table 1 shows all normalized parameters. Although the variables do not show a normal distribution, mean values were similar to median values. Normalized variables showed lower variability than absolute values. In women aged <50, higher values were observed for peak height and ETP (figure 1).
Conclusions: We found differences in Bleedscreen parameters according age and sex, for this reason we consider to establish normal values, subgroups of age and sex have to be taken into account.
To cite this abstract in AMA style:Tirado I, Vilalta N, Romero L, Vallvé C, Gich I, Souto JC, Mateo J. Normal Values in Thrombin Generation Parameters in Hemorraghic Diseases [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/normal-values-in-thrombin-generation-parameters-in-hemorraghic-diseases/. Accessed December 3, 2021.
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