Background: There is evidence of activation of the hemostasis system in the form of hypercoagulation formation during rotational work in circumpolar territories. A new promising method capable of assessing both hyper- and hypocoagulable states is the thrombin generation test.

Aims: The aim of the study is to analyze the dynamics of the parameters of the thrombin generation test (TGT) in the conditions of a trans-latitudinal Arctic sea voyage.

Methods: A prospective clinical and laboratory study was carried out on 52 subjects during the trans-latitudinal expedition “TransArktika-2019.” Plasma samples for the determination of the thrombin generation test were taken at the zero point (Arkhangelsk (64° 33′ N 40° 32′ E) prior to the ship’s voyage; and at the highest point of the expedition (Heiss Island of the Archipelago Frans – Joseph (80° 34′ N 57° 41′ E) on 18-20 days of the Arctic voyage. The determination of the parameters of thrombin kinetics was carried out on a Ceveron-alpha analyzer with a TGA-module using Ceveron TGA High reagents. Analyzed: lag phase time (tLag), time of thrombin peak formation (tPeak), thrombin peak (Peak), endogenous thrombin potential (AUC).

Results: At the high point of the tran-latitudinal voyage, the time tLag (min) and the time to reach the peak of thrombin – tPeak (min) were statistically less than at the initial zero point, which indicated a state of hypercoagulability. The AUC (nM) of the expedition members was statistically significantly higher at the high point.

Conclusions: Being in high latitudes is possibly associated with the formation of a state of hypercoagulability. The study was supported by a grant from the Russian Foundation for Basic Research – project no. 18-00-00814-KOMFI (18-00-00478).

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/on-the-diagnosis-of-thrombinemia-in-the-arctic/