Abstract Number: PO135
Meeting: ISTH 2021 Congress
Background: COVID-19 in hospital in Arkhangelsk.
Aims: The goal is to assess clinical and laboratory signs in moderately severe patients with COVID-19.
Methods: The study included patients hospitalized for COVID-19 -109 patients. On admission to the hospital, some clinical symptoms were assessed; CRP, LDH, ferritin, APTT, D-dimer, fibrinogen indicators and complete blood count (leukocyte, lymphocyte, platelet count.
Results: The average age of patients was Me [Q1-Q3] 62 [34-71] years. Upon admission to the hospital, a positive smear by the polymerase chain reaction method for the presence of coronavirus infection was determined in 60% (n = 66) of patients. Fever was reported in 60% (n = 65), in 15% of cases, patients described chest pain (n = 16), 44% of patients complained of shortness of breath (n = 49), 71% (n = 77) of patients complained of cough, sore throat and lack of sense of smell were observed in 4.6% (n = 5). In the coagulogram, all patients showed an increased level of D-dimer – 4 [0.5-8.0] mg / L, the level of fibrinogen – 4 [2.6-7.5] g/L, APTT 41, 6 [24-54] sec., There was a normal level of prothrombin time – 12 [10-17] sec. The average level of leukocytes was 8.2 [3.8-10.5] * 109 / l, lymphocytes – 30 [26-57] %, platelets – 223 [170-339] * 109 / l, ESR – 30.9 [ 10-47.5] mm / h. The values of biochemical parameters – markers of inflammation were also above the reference range: CRP – 50.4 [0.4-237] mg / L, ferritin – 563 μg /L, LDH – 638 [100-760] U / L.
Conclusions: In the initial period of the development of COVID-19 there was an increased level of thrombinemia, which indicated the presence of a risk of thromboembolic complications, but there was a tendency towards an increase in APTT.
To cite this abstract in AMA style:Vorobyeva N, Barteneva A, Lovkova I. On the Issue of Thrombinemia in Moderate COVID-19 [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/on-the-issue-of-thrombinemia-in-moderate-covid-19/. Accessed December 3, 2021.
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