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P2Y12 Receptor Gene Polymorphisms and Platelet Aggregation at Patients with Arterial Hypertension in Bukovinian Region

1Bukovinian State Medical University, Internal Medicine, Clinical Pharmacology and Occupational Diseases, Chernivtsy, Ukraine, 2Bukovinian State Medical University, Chernivtsy, Ukraine

Abstract Number: PB1725

Meeting: ISTH 2020 Congress

Theme: Platelets and Megakaryocytes » Platelet Receptors

Background: P2YT2 receptor plays a key role in platelet activation. In different researches was presented association between H1 and H2 haplotypes of P2RY12 gene and platelet aggregation (Fontana P. et al.), although, usually, it was demonstrated changes in ADP-induced level, without including spontaneous aggregation, ADP-induced time and ADP-induced speed. So, the role of H1 and H2 haplotypes at patients with arterial hypertension isn`t finally defined. Also, investigations of regional features P2Y12 gene polymorphisms and their role in cardiovascular diseases progression is still actual.

Aims: The aim of this study was to investigate association of P2Y12 polymorphisms and platelet aggregation at patients with arterial hypertension in Bukovinian region.

Methods: 101 persons with arterial hypertension were genotyped according to H1(744T) and H2 (744C) haplotypes of P2Y12 receptor. Arterial hypertension was determined due to AHA/ESC Guidelines. Platelet aggregation was investigated with method of J. Born.

Results: According to genotype presentation (H1/H1: H1/H2: H2/H2) we divided patients into the groups: homozygotes with H1/H1 genotype (34.6%), homozygotes with H2/H2 mutation (8.9%) and heterozygotes H1/H2 (56.5%).
Spontaneous aggregation of platelets was significantly lower in H1/H1 genotype (63.7±4.7%) vs. genotypes H1/H2 (72.5±8.4%) and H2/H2 (77.9±6.4%), p,p1< 0.05. The time of aggregation significantly decreased only in mutant genotype H2/H2 (55.0±35.6 sec.) vs. genotypes H1/H1 (106.7±70.2 sec.) and H1/H2 (94.5±62.0 sec.), p< 0.05. The similar feature was evaluated for ADP-depending speed of aggregation with significantly increasing in H2/H2 homozygote patients (42.6±15.6 %/min.) vs. H1/H1 (29,1±14.5 %/min.) and H1/H2 (34.8±9.8 %/min.), p< 0.05.

Conclusions: It was set association of P2RY12 gene polymorphisms, genotypes H1/H2 and H2/H2, with increased level of spontaneous platelet aggregation; we estimated higher ADP-induced speed and reduced time of aggregation at H2/H2 genotype in hypertensive patients from Bukovinian region.

To cite this abstract in AMA style:

Shorikova D, Shorikov E, Shorikov P, Khukhlina O. P2Y12 Receptor Gene Polymorphisms and Platelet Aggregation at Patients with Arterial Hypertension in Bukovinian Region [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/p2y12-receptor-gene-polymorphisms-and-platelet-aggregation-at-patients-with-arterial-hypertension-in-bukovinian-region/. Accessed January 21, 2022.

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